所有图片(1)
别名:
1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole
经验公式（希尔记法）:
C16H13Cl3N2OS
CAS号:
分子量:
387.71
EC 号:
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
NACRES:
NA.85
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质量水平
检测方案
≥96.5% (HPLC)
96.5-103.5% (NT)
97%
形式
powder
颜色
white to off-white
抗生素抗菌谱
fungi
yeast
作用机制
cell membrane | interferes
SMILES字符串
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChI key
QXHHHPZILQDDPS-UHFFFAOYSA-N
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一般描述
Chemical structure: pyrimidine
应用
Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.
生化/生理作用
Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.
包装
10G
其他说明
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
A L Fachin et al.
Medical mycology, 39(1), 129-133 (2001-03-29)
The electrophoretic pattern of the intracellular esterase of the dermatophyte Trichophyton rubrum was altered when this fungus was grown in the presence of subinhibitory concentrations of the antimycotics tioconazole or griseofulvin. All strains (original isolate and antimycotic resistant mutants) presented
Jean-Paul L Marty et al.
The Journal of dermatological treatment, 16(5-6), 299-307 (2006-01-24)
To assess the daily treatment costs and the average cost-effectiveness of three topical onychomycosis therapies - amorolfine 5% and ciclopirox 8% nail lacquers and tioconazole 28% nail solution - when used as indicated in France, the UK, Germany and Italy.
F Sidou et al.
International journal of tissue reactions, 26(1-2), 17-24 (2004-12-03)
This randomized, investigator-masked study compared the remanence on the nail surface of commercially available antimycotic nail lacquers containing amorolfine, ciclopirox and tioconazole. The lacquers, to which a coloring agent was added, were applied randomly to the left and right thumbnails
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