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质量水平
方案
≥96.5% (HPLC)
96.5-103.5% (NT)
97%
表单
powder
颜色
white to off-white
抗生素抗菌谱
fungi
yeast
作用机制
cell membrane | interferes
SMILES字符串
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChI key
QXHHHPZILQDDPS-UHFFFAOYSA-N
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相关类别
一般描述
Chemical structure: pyrimidine
应用
Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.
生化/生理作用
Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.
包装
10G
其他说明
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
E Ruckenstein et al.
International journal of pharmaceutics, 267(1-2), 121-127 (2003-11-07)
The results obtained previously by Ruckenstein and Shulgin [Int. J. Pharm. 258 (2003a) 193; Int. J. Pharm. 260 (2003b) 283] via the fluctuation theory of solutions regarding the solubility of drugs in binary aqueous mixed solvents were extended in the
Clarisse Zaitz et al.
International journal of dermatology, 45(9), 1071-1073 (2006-09-12)
The present report describes a case of onychoprotothecosis caused by Prototheca wickerhamii in a nonimmunocompromized female. Dermatological examination showed yellowish discoloration of the left and right forefinger nails, showing onicolysis and hyperkeratosis. The repeated isolation of the algae Prototheca (organisms
C Nolting et al.
Mycoses, 40 Suppl 1, 73-75 (1997-01-01)
We report on a 75 year old patient with a bronchial asthma treated at least for 15 years with low dose prednisolone. Under this treatment he developed a tinea follicularis and was demonstrated in our clinic with papulopustular skin lesions
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