推荐产品
质量水平
方案
≥96.5% (HPLC)
96.5-103.5% (NT)
97%
表单
powder
颜色
white to off-white
抗生素抗菌谱
fungi
yeast
作用机制
cell membrane | interferes
SMILES字符串
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChI key
QXHHHPZILQDDPS-UHFFFAOYSA-N
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相关类别
一般描述
Chemical structure: pyrimidine
应用
Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.
生化/生理作用
Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.
包装
10G
其他说明
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
J R Dean et al.
Journal of AOAC International, 80(1), 7-13 (1997-01-01)
Supercritical fluid extraction (SFE) followed by packed column supercritical fluid chromatography with ultraviolet detection was evaluated as a quantitative method for determining 4 antifungals (fluconazole, tioconazole, hexaconazole, and UK-47,265) in rodent diet. Chromatography was achieved with a cyano-bonded silica column
M Pereira et al.
Mycopathologia, 143(2), 71-75 (1999-04-17)
Understanding the genetic mechanisms involved in resistance to antifungal agents is important in the fight against pathogenic fungi. In the present investigation we studied a strain of the model fungus Aspergillus nidulans which presents resistance to tioconazole and behaves as
F Sidou et al.
International journal of tissue reactions, 26(1-2), 17-24 (2004-12-03)
This randomized, investigator-masked study compared the remanence on the nail surface of commercially available antimycotic nail lacquers containing amorolfine, ciclopirox and tioconazole. The lacquers, to which a coloring agent was added, were applied randomly to the left and right thumbnails
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