03907
噻康唑
97%
别名:
1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole
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关于此项目
经验公式（希尔记法）:
C16H13Cl3N2OS
化学文摘社编号:
分子量:
387.71
EC 号:
MDL编号:
UNSPSC代码:
51302325
PubChem化学物质编号:
NACRES:
NA.85
质量水平
方案
≥96.5% (HPLC)
96.5-103.5% (NT)
97%
表单
powder
颜色
white to off-white
抗生素抗菌谱
fungi
yeast
作用机制
cell membrane | interferes
SMILES字符串
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChI key
QXHHHPZILQDDPS-UHFFFAOYSA-N
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一般描述
Chemical structure: pyrimidine
应用
Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.
生化/生理作用
Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.
包装
10G
其他说明
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
A Defontaine et al.
Journal of medical microbiology, 48(7), 663-670 (1999-07-14)
A commercially available disk diffusion procedure was used in a large-scale study to evaluate the susceptibility of a wide range of Candida isolates to polyenes and azoles. With almost all isolates of C. glabrata resistant colonies were present within the
A J Carrillo-Muñoz et al.
Chemotherapy, 50(6), 308-313 (2004-12-21)
We have tested 250 strains belonging to 15 species of clinically important dermatophytes and Scopulariopsis against ten antifungal drugs using an agar diffusion method (NeoSensitabstrade mark, Rosco, Taastrup, Denmark). Some of the experimental factors were adapted to dermatophyte development, such
Giovanna Simonetti et al.
International journal of antimicrobial agents, 22(4), 439-443 (2003-10-03)
Tioconazole (TCZ) killed resistant Candida albicans in less than 3 min, after the addition of butylated hydroxyanisole (BHA), a phenolic antioxidant, at subinhibitory concentrations. The bactericidal activity was also rapid against resistant Escherichia coli. BHA increased the TCZ activity in
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