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About This Item
线性分子式:
Na2SeO4
CAS号:
分子量:
188.94
EC 号:
MDL编号:
UNSPSC代码:
12352302
PubChem化学物质编号:
NACRES:
NA.55
方案:
≥95% (elemental analysis)
表单:
powder or crystals
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质量水平
方案
≥95% (elemental analysis)
表单
powder or crystals
pH值（酸碱度）
5.5-7.5 (25 °C, 18.9 g/L)
SMILES字符串
[Na+].[Na+].[O-][Se]([O-])(=O)=O
InChI
1S/2Na.H2O4Se/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
InChI key
MHQOTKLEMKRJIR-UHFFFAOYSA-L
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应用
- Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/Caspase-1 pathway.: This study demonstrates that selenium nanoparticles, including sodium selenate, mitigate acute kidney injury caused by ischemia reperfusion. The nanoparticles modulate key pathways, offering potential therapeutic applications in renal injury treatment (Wang et al., 2022).
- Phosphoproteomic profiling of selenate-treated Alzheimer′s disease model cells.: This research provides a detailed phosphoproteomic profile of Alzheimer′s disease model cells treated with sodium selenate, uncovering its effects on protein phosphorylation and implications for neuroprotection (Chen et al., 2014).
警示用语：
Danger
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - STOT RE 2
储存分类代码
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
危险化学品
剧毒化学品
Ilona Benko et al.
Environmental toxicology and chemistry, 31(12), 2812-2820 (2012-08-29)
Sixteen groups of mice were fed diets containing different selenium species to compare their toxicity. Inorganic sodium selenate and sodium hydroselenite, elementary nanoSe, organic Sel-Plex, and Lacto-MicroSelenium were administered for 14 d at concentrations of 0.5, 5, and 50 ppm
Ian K Lai et al.
Toxicological sciences : an official journal of the Society of Toxicology, 124(1), 202-214 (2011-08-26)
Homeostasis of selenium (Se), a critical antioxidant incorporated into amino acids and enzymes, is disrupted by exposure to aryl hydrocarbon receptor (AhR) agonists. Here we examined the importance of dietary Se in preventing the toxicity of the most toxic polychlorinated
N M Corcoran et al.
British journal of cancer, 103(4), 462-468 (2010-07-22)
Angiogenesis is fundamental to the progression of many solid tumours including prostate cancer. Sodium selenate is a small, water-soluble, orally bioavailable activator of PP2A phosphatase with anti-angiogenic properties. This was a dose-escalation phase I study in men with asymptomatic, chemotherapy-naïve
Nigel C Jones et al.
Neurobiology of disease, 45(3), 897-901 (2011-12-21)
Tau hyperphosphorylation has been implicated in the pathogenesis of a variety of forms of human epilepsy. Here we investigated whether treatment with sodium selenate, a drug which reduces pathological hyperphosphorylated tau by enhancement of PP2A activity, would inhibit seizures in
Janet van Eersel et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(31), 13888-13893 (2010-07-21)
Alzheimer's disease (AD) brains are characterized by amyloid-beta-containing plaques and hyperphosphorylated tau-containing neurofibrillary tangles (NFTs); however, in frontotemporal dementia, the tau pathology manifests in the absence of overt amyloid-beta plaques. Therapeutic strategies so far have primarily been targeting amyloid-beta, although
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