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安全信息

A1010

Sigma-Aldrich

氧化砷(III)

ReagentPlus®, ≥99.0%

别名:

三氧化二砷, 亚砷酸

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About This Item

经验公式（希尔记法）:
As2O3
CAS号:
1327-53-3
分子量:
197.84
EC 号:
215-481-4
MDL编号:
MFCD00003433
UNSPSC代码:
12171602
PubChem化学物质编号:
329770647
NACRES:
NA.55
方案:
≥99.0%
表单:
powder

蒸汽压

0 hPa ( 66 °C)

质量水平

200

产品线

ReagentPlus®

方案

≥99.0%

表单

powder

储存温度

room temp

SMILES字符串

O=[As]O[As]=O

InChI

1S/As2O3/c3-1-5-2-4

InChI key

IKWTVSLWAPBBKU-UHFFFAOYSA-N

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相关类别

一般描述

氧化砷（III），也称为三氧化二砷，是一种可用作合成多种砷基化合物原料的两性氧化物。它可用于使玻璃和搪瓷脱色。它在治疗急性早幼粒细胞白血病（APL）中的功效已被研究。

应用

氧化砷（III）已被用于一项详细研究三氧化二砷与γ辐射结合以阐明血红蛋白（Hb）效果的研究中。

生化/生理作用

针对急性早幼粒细胞白血病（APL）的强效剂。引起皮肤癌、肺癌和膀胱癌。

法律信息

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1

靶器官

Respiratory system,Cardio-vascular system,Gastrointestinal tract

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
BCCL3474
BCCM5851
BCCJ8941
BCCG8449
BCCG0159

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How should product A1010, Arsenic(III) oxide be dissolved?

    This product is soluble in 1 M NaOH  at 66 mg/ml, with heat as needed, yielding a clear, colorless solution.  This information can be found on the Product Information Sheet.

  6. What is the solution stablity of A1010, Arsenic(III) oxide?

    We do not have any solution stability data for product A1010. Thus it is best to make up fresh solutions of A1010.

  7. What is the difference between Product Nos. A1010 and 202673, Arsenic(III) oxide?

    Both products are Arsenic(III) oxide.  The specifications for the products differ. Please see the Specification Sheets for details.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Wilson H Miller et al.
Cancer research, 62(14), 3893-3903 (2002-07-19)
Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsed patients with acute promyelocytic leukemia (APL). As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations
Combined effect of arsenic trioxide and radiation on physical properties of hemoglobin biopolymer.
Saad-El-Din AA, et al.
Journal of Radiation Research and Applied Sciences, 7(2), 411-416 (2014)
E Lengfelder et al.
Leukemia, 26(3), 433-442 (2011-09-10)
Arsenic trioxide (ATO) is presently the most active single agent in the treatment of acute promyelocytic leukemia (APL). This review provides insights into the mode of action and the pharmacological properties of ATO, and summarizes the most relevant results of
Dikshith TSS
Handbook of Chemicals and Safety, 92-92 (1992)
Z X Shen et al.
Blood, 89(9), 3354-3360 (1997-05-01)
The therapeutic effect of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) was evaluated among 15 APL patients at relapse after all-trans retinoic acid (ATRA) induced and chemotherapy maintained complete remission (CR). As2O3 was administered intravenously at
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