所有图片(1)
About This Item
经验公式（希尔记法）:
C5H11N
CAS号:
分子量:
85.15
Beilstein:
102438
EC 号:
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.21
等级:
biotech. grade
方案:
≥99.5%
技术:
DNA sequencing: suitable
沸点:
106 °C (lit.)
106 °C
106 °C
蒸汽压:
23 mmHg ( 20 °C)
推荐产品
等级
biotech. grade
质量水平
蒸汽密度
3 (vs air)
蒸汽压
23 mmHg ( 20 °C)
方案
≥99.5%
表单
liquid
技术
DNA sequencing: suitable
杂质
<0.3% water
折射率
n20/D 1.452 (lit.)
沸点
106 °C (lit.)
106 °C
mp
−13 °C (lit.)
溶解性
organic solvents: soluble(lit.)
water: miscible(lit.)
密度
0.862 g/mL at 20 °C (lit.)
λ
1 cm path, H2O reference
紫外吸收
λ: 290 Amax: <1.000
λ: 370 Amax: <0.050
SMILES字符串
C1CCNCC1
InChI
1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
InChI key
NQRYJNQNLNOLGT-UHFFFAOYSA-N
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一般描述
Piperidine, a heterocyclic cyclohexane is a volatile secondary amine. Maxam-Gilbert chemical method, a DNA sequencing technology employs piperidine to rupture DNA strands at damaged base site. Its crystal structure analyzed at 150K shows hydrogen bonding between NH groups. Piperidine ring forms a part of many naturally occuring alkaloids. It is prepared on an industrial scale by the hydrogenation of pyridine in the presence of nickel catalyst. The 1H NMR spectrum of piperidine has been recorded.
应用
适用于 Applied Biosystems 431 和 433A 多肽合成仪。
Piperidine has been used in combination with DMF (dimethylformamide) for the removal of Fmoc (fluorenylmethyloxycarbonyl) group from the N-terminal amino group during peptide synthesis.
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
60.8 °F - closed cup
闪点(°C)
16 °C - closed cup
法规信息
易制毒化学品（2类）
危险化学品
W B Mattes et al.
Biochimica et biophysica acta, 868(1), 71-76 (1986-10-16)
The volatile, secondary amine piperidine is used in the Maxam-Gilbert chemical method of DNA sequencing to create strand breaks in DNA at sites of damaged bases. As such it is often used in generalized studies of DNA damage to identify
Peptide Synthesis.
Miao Z and Cheng Z
Bio-protocol, 2(14) (2012)
Andrew Parkin et al.
Acta crystallographica. Section B, Structural science, 60(Pt 2), 219-227 (2004-03-16)
The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so
Marek Łuczkowski et al.
Inorganic chemistry, 47(23), 10875-10888 (2008-10-31)
A de novo protein design strategy provides a powerful tool to elucidate how heavy metals interact with proteins.Cysteine derivatives of the TRI peptide family (Ac-G(LKALEEK)4G-NH2) have been shown to bind heavy metals in an unusual trigonal geometry. Our present objective
Xuwang Chen et al.
Bioorganic & medicinal chemistry, 20(12), 3856-3864 (2012-05-18)
A novel series of piperidine-linked amino-triazine derivatives were designed, synthesized and evaluated for in vitro anti-HIV activity as non-nucleoside reverse transcriptase inhibitors on the basis of our previous work. Screening results indicated that most compounds showed excellent activity against wild-type
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