推荐产品
等级
pharmaceutical primary standard
API类
etacrynic acid
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
格式
neat
储存温度
2-8°C
SMILES字符串
ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
InChI
1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
InChI key
AVOLMBLBETYQHX-UHFFFAOYSA-N
基因信息
human ... SLC12A1(6557)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Etacrynic acid for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ethacrynic acid and related diuretics: relationship of structure to beneficial and detrimental actions.
Annual review of pharmacology and toxicology, 21, 265-293 (1981-01-01)
[Clinical pharmacology of diuretics with special reference to furosemide and ethacrynic acid].
Postepy higieny i medycyny doswiadczalnej, 34(1), 47-74 (1980-01-01)
[Ethacrynic acid].
La Clinica terapeutica, 37(4), 350-369 (1966-05-31)
Toxicity of ethacrynic acid and furosemide.
American heart journal, 85(6), 831-834 (1973-06-01)
Xenobiotica; the fate of foreign compounds in biological systems, 23(8), 913-923 (1993-08-01)
1. The diuretic drug ethacrynic acid (EA) is a potent reversible inhibitor of rat and human glutathione S-transferases (GST), with I50-values (microM) of 4.6-6.0, 0.3-1.9 and 3.3-4.8 for alpha, mu and pi-class, respectively. 2. The reversible inhibition by the glutathione
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