等级
pharmaceutical primary standard
API类
aristolochia
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
格式
neat
SMILES字符串
COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C(O)=O
InChI
1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)
InChI key
BBFQZRXNYIEMAW-UHFFFAOYSA-N
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Journal of ethnopharmacology, 125(1), 108-144 (2009-06-10)
More than 100 cases of nephropathy over the last 10 years caused by the systemic and longer term application of Chinese snakeroot (Aristolochia fangchi) highlighted the risk of using preparations which contain aristolochic acids. On the other hand anecdotal evidence
International journal of cancer, 135(2), 502-507 (2014-06-13)
Aristolochic acid (AA) causes aristolochic acid nephropathy (AAN), first described in women in Belgium accidently prescribed Aristolochia fangchi in a slimming treatment, and also Balkan endemic nephropathy (BEN), through probable dietary contamination with Aristolochia clematitis seeds. Both nephropathies have a
A Balkan riddle's serendipitous solution.
Science (New York, N.Y.), 344(6180), 146-146 (2014-04-12)
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 31(19), 1573-1575 (2006-12-15)
Aristolochic acid I (AA-I) was absorbed and distributed quickly in vivo, the plasma concentration-time curve were fit with the open two-compartment model and one-compartment model, respectively. The elimination of AA-I has relationship with the dosage, the low dose group eliminates
American journal of physiology. Renal physiology, 308(2), F122-F130 (2014-11-28)
Tissue fibrosis is a major cause of death in developed countries. It commonly occurs after either acute or chronic injury and affects diverse organs, including the heart, liver, lung, and kidney. Using the renal ablation model of chronic kidney disease
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