推荐产品
等级
pharmaceutical primary standard
API类
dacarbazine
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
InChI
1S/C4H3N5O/c10-4-2-3(6-1-5-2)7-9-8-4/h1,9H,(H,8,10)
InChI key
WXKVKFJUCMCVFI-UHFFFAOYSA-N
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相关类别
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Dacarbazine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
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P P Saunders et al.
Chemico-biological interactions, 58(3), 319-331 (1986-06-01)
Decomposition of the antitumor agent 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC, Dacarbazine) produces several potentially toxic compounds, the concentration of which depend on incubation parameters such as pH, temperature and illumination. The action of DTIC on chinese hamster ovary (CHO) cell clone formation in
Disclosure of the "fairy" of fairy-ring-forming fungus Lepista sordida.
Jae-Hoon Choi et al.
Chembiochem : a European journal of chemical biology, 11(10), 1373-1377 (2010-05-21)
L L Bennett et al.
Biochemical pharmacology, 34(8), 1293-1304 (1985-04-15)
The metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine were studied to elucidate the biochemical basis for their known cytotoxicities. 2-Azaadenosine is a known substrate for adenosine kinase. That 2-azahypoxanthine is a substrate for hypoxanthine (guanine) phosphoribosyltransferase is shown by
B Hernández et al.
Journal of computer-aided molecular design, 11(2), 153-162 (1997-03-01)
The tautomerism of 2-azaadenine and 2-hypoxanthine has been examined in the gas phase and in aqueous solution. The tautomerism in the gas phase has been studied by means of semiempirical and ab initio quantum-mechanical computations, as well as density-functional calculations.
D Fiore et al.
Antimicrobial agents and chemotherapy, 27(6), 977-979 (1985-06-01)
A high-pressure liquid chromatographic method has been developed that allows for the simultaneous analysis of dacarbazine (DTIC), 5-aminoimidazole-4-carboxamide (AIC), and 2-azahypoxanthine (2-AZA) in plasma or urine. Plasma samples were prepared by ultrafiltration, whereas urine samples were filtered and diluted for
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