产品名称
来氟米特杂质A, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2
SMILES string
Nc1ccc(cc1)C(F)(F)F
InChI key
ODGIMMLDVSWADK-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
leflunomide
manufacturer/tradename
EDQM
refractive index
n20/D 1.483 (lit.)
bp
83 °C/12 mmHg (lit.)
density
1.283 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
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Application
Leflunomide impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
P M Sharp
Gene, 139(1), 135-136 (1994-02-11)
Three previously unrecognized genes from Bacillus licheniformis, Thermus thermophilus and Thermotoga maritima, encoding ribosomal protein L33, have been identified and designated as rpmG genes. Their sequence and context have been compared with the three known rpmG genes from Escherichia coli
L Sebestová et al.
Toxicology, 92(1-3), 27-38 (1994-09-06)
Three isomers of trifluoromethylaniline (TFMA) were investigated for their possible different toxic effects on the hematopoietic system in male Wistar rats. The effects of isomeric 2-, 3- and 4-TFMA were compared with those of aniline, the prototypic drug. Strong leukocytosis
Ribosomal proteins S3a, S13, S16, and S24 are not mutated in patients with Diamond-Blackfan anemia.
R Cmejla et al.
Blood, 97(2), 579-580 (2001-02-24)
Giorgio Mangiarotti
Biochemistry and cell biology = Biochimie et biologie cellulaire, 80(2), 261-270 (2002-05-07)
Ribosomal protein mRNAs left over from growth are selectively excluded from polyribosomes in the first half of Dictyostelium discoideum development. This is due to the fact that they are sequestered by a class of free 40S ribosomal subunits, characterized by
S H Coleman et al.
Journal of general microbiology, 139(4), 707-716 (1993-04-01)
The rpmB,G operon of Escherichia coli codes for the synthesis of ribosomal proteins L28 and L33. In one mutant strain (TP28), these two proteins are made at about half their normal rates, ribosome assembly is greatly perturbed and precursor particles
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