SMILES string
[S](=O)(=O)(O)CCO.Brc1c(ccc(c1)\C(=N\[H])\N)OCCCOc2c(cc(cc2)\C(=N\[H])\N)Br
InChI
1S/C17H18Br2N4O2.C2H6O4S/c18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19;3-1-2-7(4,5)6/h2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23);3H,1-2H2,(H,4,5,6)
InChI key
BZACJASHKPPTKX-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
dibrompropamidine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Dibrompropamidine diisetionate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
P Wright et al.
The British journal of ophthalmology, 69(10), 778-782 (1985-10-01)
The first medical cure of a corneal infection due to an Acanthamoeba species is reported. The 44-year-old patient developed a suppurative keratitis associated with an epithelial defect, hypopyon, and secondary glaucoma. Acanthamoeba was confirmed as the causative agent four months
R M Richards et al.
Journal of pharmaceutical sciences, 80(9), 861-867 (1991-09-01)
Modifications of antibacterial activity have been demonstrated using combinations of two antibacterials from trimethoprim, sulfonamides (sulfadiazine, sulfamerazine, and silver sulfadiazine), silver nitrate, and dibromopropamidine isethionate, either formulated in a cream base or dissolved in peptone water. The creams were evaluated
Cosmetic contact lens-related Acanthamoeba keratitis.
James McKelvie et al.
Clinical & experimental ophthalmology, 37(4), 419-420 (2009-07-15)
M R Richards et al.
The Journal of pharmacy and pharmacology, 46(7), 563-566 (1994-07-01)
Combinations of polymyxin B and dibromopropamidine isethionate exhibited synergistic inhibitory and bactericidal activity against Pseudomonas aeruginosa, Enterobacter cloacae, Proteus mirabilis, Escherichia coli and Staphylococcus aureus. Similar results were obtained with polymyxin B plus propamidine combinations except that propamidine was not
S S Asghar et al.
Biochimica et biophysica acta, 317(2), 539-548 (1973-08-30)
A series of amidino compounds has been investigated for their inhibitory effects on C1s, C1r, and generation of C1s. Diamidines consisting of two amidinophenyl residues linked in para position by a molecular bridge proved to be the strongest competitive inhibitors
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