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Merck
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主要文件

Y0000479

氯丙嗪杂质D

European Pharmacopoeia (EP) Reference Standard

别名:

Desmethylchlorpromazine, 3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine

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About This Item

经验公式(希尔记法):
C16H17ClN2S
CAS号:
分子量:
304.84
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

chlorpromazine

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCCNC

InChI

1S/C16H17ClN2S/c1-18-9-4-10-19-13-5-2-3-6-15(13)20-16-8-7-12(17)11-14(16)19/h2-3,5-8,11,18H,4,9-10H2,1H3

InChI key

YHFXGBOUSIKGMZ-UHFFFAOYSA-N

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Chlorpromazine impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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G Alfredsson et al.
Acta psychiatrica Scandinavica. Supplementum, 311, 49-74 (1984-01-01)
Schizophrenic patients were treated with fixed doses of sulpiride (800 mg) or chlorpromazine (400 mg) during eight weeks using a double-blind design. In order to examine relationships between pharmacokinetic, clinical and biochemical parameters in relation to treatment the following variables
M Chetty et al.
Therapeutic drug monitoring, 13(4), 350-355 (1991-07-01)
The concentrations of chlorpromazine (CPZ) and six of its metabolites in patient plasma samples that had been stored for 24 h at -20 degrees C, for 1 week at -20 degrees C, and for 4 weeks at -70 degrees C
G P Sgaragli et al.
Bollettino della Societa italiana di biologia sperimentale, 60(9), 1727-1733 (1984-09-30)
Data obtained in this preliminary study show that in patients chronically treated either with Chlorimipramine (n = 6) or with Chlorpromazine (n = 2), significant amounts of the corresponding Nor1- and Nor2-metabolites were detected in plasma. The role of these
R C Young
Therapeutic drug monitoring, 8(1), 23-26 (1986-01-01)
Plasma nor1-chlorpromazine (nor1-CPZ) and chlorpromazine concentrations were measured by gas chromatography--mass fragmentometry in 15 inpatients receiving stable doses of chlorpromazine. Nor1-CPZ concentrations averaged 20% of chlorpromazine concentrations and were highly correlated with them. Relative concentrations of nor1-CPZ increased with age.
[Dehalogenation and N-dealkylation of chlorpromazine in patients undergoing chronic treatment].
R Ninci et al.
Bollettino della Societa italiana di biologia sperimentale, 61(8), 1101-1104 (1985-08-30)

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