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Merck
CN
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主要文件

Y0000479

氯丙嗪杂质D

European Pharmacopoeia (EP) Reference Standard

别名:

Desmethylchlorpromazine, 3-(2-Chloro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine

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About This Item

经验公式(希尔记法):
C16H17ClN2S
CAS号:
分子量:
304.84
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

chlorpromazine

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCCNC

InChI

1S/C16H17ClN2S/c1-18-9-4-10-19-13-5-2-3-6-15(13)20-16-8-7-12(17)11-14(16)19/h2-3,5-8,11,18H,4,9-10H2,1H3

InChI key

YHFXGBOUSIKGMZ-UHFFFAOYSA-N

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Chlorpromazine impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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J L Borowitz et al.
Research communications in chemical pathology and pharmacology, 48(2), 305-308 (1985-05-01)
Although no differences in membrane stabilization by calcium were noted between leukemic (P-388) and normal murine leukocytes, tumor cells were shown to be more resistant to damage by ethanol but not by desmethylchlorpromazine. Furthermore, verapamil protected tumor cells but not
D L Newton et al.
Biochemistry, 28(9), 3750-3757 (1989-05-02)
In the presence of Ca2+ norchlorpromazine isothiocyanate forms a monocovalent complex with calmodulin: CAPP1-calmodulin (Newton et al, 1983). Trypsin digestion of [3H]CAPP1-calmodulin yields as the major radioactive peptide N epsilon-CAPP-Lys-Met-Lys, corresponding to residues 75-77 of calmodulin. Stoichiometric amounts of all
G P Sgaragli et al.
Bollettino della Societa italiana di biologia sperimentale, 60(9), 1757-1763 (1984-09-30)
Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of accuracy and precision with
R Ninci et al.
Journal of chromatography, 381(2), 315-322 (1986-09-05)
A gas chromatographic method using nitrogen-selective detection for the quantitative determination of nanogram amounts of chlorimipramine, chlorpromazine and their nor1 and nor2 derivatives in plasma is described. Derivatization with trifluoroacetic anhydride of nor1 and nor2 metabolites allowed the chromatographic separation
R C Young
Therapeutic drug monitoring, 8(1), 23-26 (1986-01-01)
Plasma nor1-chlorpromazine (nor1-CPZ) and chlorpromazine concentrations were measured by gas chromatography--mass fragmentometry in 15 inpatients receiving stable doses of chlorpromazine. Nor1-CPZ concentrations averaged 20% of chlorpromazine concentrations and were highly correlated with them. Relative concentrations of nor1-CPZ increased with age.

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