推荐产品
等级
pharmaceutical primary standard
API类
acebutolol
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
N(C(C)C)CC(O)COc1c(cc(cc1)NC(=O)C)C(=O)C
InChI
1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)
InChI key
AWOGXJOBNAWQSF-UHFFFAOYSA-N
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相关类别
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
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产品编号
说明
价格
High-performance liquid chromatographic determination of diacetolol enantiomers.
M Piquette-Miller et al.
Journal of chromatography, 533, 300-303 (1990-11-30)
M Piquette-Miller et al.
Journal of pharmaceutical sciences, 80(4), 313-316 (1991-04-01)
The chiral beta-blocker acebutolol (AC) is marketed as a racemic mixture. Both AC and its major metabolite, diacetotol (DC), are chiral, the S-enantiomer possessing beta-blocking activity. The pharmacokinetics of AC and DC enantiomers was determined in 12 healthy subjects following
B N Singh et al.
Pharmacotherapy, 6(2), 45-63 (1986-03-01)
Acebutolol is a new hydrophilic, cardioselective beta-adrenergic-blocking agent that possesses partial agonist and membrane-stabilizing activities. In the treatment of mild to moderate essential hypertension, once-daily acebutolol as monotherapy provides effective control in a large majority of patients and produces a
J Mantz et al.
Journal of cardiothoracic anesthesia, 4(5), 577-581 (1990-10-01)
Cardiopulmonary bypass (CPB) has been reported to alter the disposition of numerous drugs and consequently to modify their plasma levels. The present study was designed to delineate the time course of acebutolol (a cardioselective beta-blocker) and diacetolol (its main metabolite)
S Abolfazl Mostafavi et al.
International journal of pharmaceutics, 255(1-2), 81-86 (2003-04-04)
Acebutolol (AC) is a chiral beta-adrenergic receptor-blocking agent, which has been shown to be clinically effective in hypertension. The plasma concentration-time profiles of AC exhibit two peaks following oral administration of racemate for both R- and S-enantiomers. In the present
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