等级
pharmaceutical primary standard
API类
tramadol
制造商/商品名称
EDQM
药品控制
USDEA Schedule IV
应用
pharmaceutical (small molecule)
格式
neat
储存温度
2-8°C
SMILES字符串
Cl.COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C
InChI
1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1
InChI key
PPKXEPBICJTCRU-XMZRARIVSA-N
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Tramadol is a synthetic opiate agonist analgesic, widely used in patients suffering from moderate to severe chronic pain. It is considered safe when compared to other opioids. It contributes to the analgesic activity by blocking the nociceptive impulses at the spinal level, inhibiting the norepinephrine and serotonin reuptake.
Tramadol is a synthetic opiate agonist analgesic, widely used in patients suffering from moderate to severe chronic pain. It is considered safe when compared to other opioids. It contributes to the analgesic activity by blocking the nociceptive impulses at the spinal level, inhibiting the norepinephrine and serotonin reuptake.
应用
This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.
生化/生理作用
Opioid analgesic; P450 substrate.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3
靶器官
Central nervous system
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Application of HPLC for the simultaneous determination of aceclofenac, paracetamol and tramadol hydrochloride in pharmaceutical dosage form
Chandra P, et al.
Scientia Pharmaceutica, 80(2), 337-352 (2012)
Analgesic oral efficacy of tramadol hydrochloride in postoperative pain
Sunshine A, et al.
Clinical Pharmacology and Therapeutics, 51(6), 740-746 (1992)
Kinetic spectrophotometric determination of tramadol hydrochloride in pharmaceutical formulation
Abdellatef EH
Journal of Pharmaceutical and Biomedical Analysis, 29(5), 835-842 (2002)
The clinical use of tramadol hydrochloride
Bamigbade AT and Langford MR
Pain, 5(6), 155-182 (1998)
HPLC determination and validation of tramadol hydrochloride in capsules
Kartinasari FW, et al.
Journal of Liquid Chromatography and Related Technologies, 27(4), 737-744 (2004)
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