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经验公式（希尔记法）:
C14H12ClNO2
化学文摘社编号:
分子量:
261.70
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
托芬那酸, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
SMILES string
Cc1c(Cl)cccc1Nc2ccccc2C(O)=O
InChI key
YEZNLOUZAIOMLT-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
tolfenamic acid
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Application
Tolfenamic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
S B Pedersen
Pharmacology & toxicology, 75 Suppl 2, 22-32 (1994-01-01)
The pharmacokinetics of tolfenamic acid is well described by a two-compartment model with relatively short half-lives (T/2 beta 1-2 hours) and tolfenamic acid is highly protein-bound with small volumes of distribution. It is cleared relatively fast (150-200 ml/min), mainly by
Gastrointestinal tolerance studies on tolfenamic acid in humans and animals.
O Eskerod
Pharmacology & toxicology, 75 Suppl 2, 44-48 (1994-01-01)
P E Hansen
Pharmacology & toxicology, 75 Suppl 2, 81-82 (1994-01-01)
The possible role of prostaglandins (PGs) in migraine has been the subject of increasing attention after the rather dramatic experiments done in man by Bergström and coworkers more than 25 years ago (1965). The role of PGs in migraine, however
The overall safety of tolfenamic acid.
J Hendel
Pharmacology & toxicology, 75 Suppl 2, 53-55 (1994-01-01)
H Vapaatalo
Pharmacology & toxicology, 75 Suppl 2, 76-80 (1994-01-01)
Migraine is a paroxysmal disorder characterized by recurrent attacks of headache, with or without associated visual and gastrointestinal disturbances. Migraine can be classified in two main groups, common and classic. Theories trying to explain the pathogenesis of a migraine attack
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