推荐产品
等级
pharmaceutical primary standard
API类
tolfenamic acid
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
Cc1c(Cl)cccc1Nc2ccccc2C(O)=O
InChI
1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
InChI key
YEZNLOUZAIOMLT-UHFFFAOYSA-N
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相关类别
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Tolfenamic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生化/生理作用
Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
H Isomäki
Pharmacology & toxicology, 75 Suppl 2, 64-65 (1994-01-01)
Tolfenamic acid (TA) is an interesting drug for the treatment of rheumatic diseases because of its capacity to inhibit the synthesis of leukotrienes. It may have fewer upper gastrointestinal side effects than other NSAIDs which inhibit only the synthesis of
Tolfenamic acid and leukotriene synthesis inhibition.
E Moilanen et al.
Pharmacology & toxicology, 75 Suppl 2, 60-63 (1994-01-01)
The overall safety of tolfenamic acid.
J Hendel
Pharmacology & toxicology, 75 Suppl 2, 53-55 (1994-01-01)
P E Hansen
Pharmacology & toxicology, 75 Suppl 2, 81-82 (1994-01-01)
The possible role of prostaglandins (PGs) in migraine has been the subject of increasing attention after the rather dramatic experiments done in man by Bergström and coworkers more than 25 years ago (1965). The role of PGs in migraine, however
S B Pedersen
Pharmacology & toxicology, 75 Suppl 2, 22-32 (1994-01-01)
The pharmacokinetics of tolfenamic acid is well described by a two-compartment model with relatively short half-lives (T/2 beta 1-2 hours) and tolfenamic acid is highly protein-bound with small volumes of distribution. It is cleared relatively fast (150-200 ml/min), mainly by
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