跳转至内容
Merck
CN
所有图片(4)

文件

安全信息

V8388

Sigma-Aldrich

长春新碱 硫酸酯

meets USP testing specifications

别名:

长春新碱 硫酸盐, VCR, 醛基长春碱 硫酸盐, 长春醛碱 硫酸盐

登录查看公司和协议定价
所有图片(4)

About This Item

经验公式（希尔记法）:
C46H56N4O10 · H2SO4
CAS号:
2068-78-2
分子量:
923.04
Beilstein:
3924631
EC 号:
218-190-0
MDL编号:
MFCD00084729
UNSPSC代码:
12352210
PubChem化学物质编号:
24900771
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

质量水平

200

溶解性

ethanol: slightly soluble
methanol: soluble
water: freely soluble

抗生素抗菌谱

neoplastics

应用

pharmaceutical (small molecule)

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1

InChI

1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChI key

AQTQHPDCURKLKT-PNYVAJAMSA-N

正在寻找类似产品? 访问 产品对比指南

相关类别

一般描述

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.

应用

use product name over-ride for USP name - jk 6/2/2005
Vincristine sulfate has been used:
  • as a positive control in potato disc anti-tumor bioassay
  • as a standard cytotoxic agent
  • to treat cells for manipulation of the microtubule network

生化/生理作用

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H300,H341,H361fd

危险分类

Acute Tox. 2 Oral - Muta. 2 - Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact 客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Molecularly characterized solvent extracts and saponins from Polygonum hydropiper L. show high anti-angiogenic, anti-tumor, brine shrimp, and fibroblast NIH/3T3 cell line cytotoxicity
Ayaz M, et al.
Frontiers in Pharmacology, 7, 74-74 (2016)
Haq Nawaz et al.
The Analyst, 138(20), 6177-6184 (2013-08-24)
Understanding the interaction of anticancer drugs with model cell lines is important to elucidate the mode of action of these drugs as well as to develop cost effective and rapid screening methods. Raman spectroscopy has been demonstrated to be a
Nicole D Paris et al.
Scientific reports, 10(1), 19501-19501 (2020-11-13)
Pediatric cancer treatment often involves chemotherapy and radiation, where off-target effects can include skeletal muscle decline. The effect of such treatments on juvenile skeletal muscle growth has yet to be investigated. We employed a small animal irradiator to administer fractionated
The polyomavirus BK agnoprotein co-localizes with lipid droplets
Unterstab G, et al.
Virology, 399(2), 322-331 (2010)
Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum
Karioti A, et al.
Phytochemistry, 68(11), 1587-1594 (2007)
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门