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安全信息

V8388

Sigma-Aldrich

长春新碱 硫酸酯

meets USP testing specifications

别名:

长春新碱 硫酸盐, VCR, 醛基长春碱 硫酸盐, 长春醛碱 硫酸盐

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About This Item

经验公式（希尔记法）:
C46H56N4O10 · H2SO4
CAS号:
2068-78-2
分子量:
923.04
Beilstein:
3924631
EC 号:
218-190-0
MDL编号:
MFCD00084729
UNSPSC代码:
12352210
PubChem化学物质编号:
24900771
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

质量水平

200

溶解性

ethanol: slightly soluble
methanol: soluble
water: freely soluble

抗生素抗菌谱

neoplastics

应用

pharmaceutical (small molecule)

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1

InChI

1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChI key

AQTQHPDCURKLKT-PNYVAJAMSA-N

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相关类别

一般描述

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.

应用

use product name over-ride for USP name - jk 6/2/2005
Vincristine sulfate has been used:
  • as a positive control in potato disc anti-tumor bioassay
  • as a standard cytotoxic agent
  • to treat cells for manipulation of the microtubule network

生化/生理作用

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H300,H341,H361fd

危险分类

Acute Tox. 2 Oral - Muta. 2 - Repr. 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number
0000389773
0000332138
0000308038
0000389773
0000332138

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