等级
pharmaceutical primary standard
Agency
EP Reference Standard
API类
valproic acid
制造商/商品名称
EDQM
折射率
n20/D 1.425 (lit.)
沸点
220 °C (lit.)
密度
0.9 g/mL at 25 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
CCCC(C(O)=O)CCC
InChI
1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
InChI key
NIJJYAXOARWZEE-UHFFFAOYSA-N
基因信息
human ... ALDH5A1(7915)
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警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
231.8 °F - closed cup
闪点(°C)
111 °C - closed cup
Taylor Chomiak et al.
Neurotoxicology and teratology, 36, 57-66 (2012-09-13)
Autism spectrum disorder (ASD) is a behaviourally defined brain disorder affecting approximately 1 in 88 children. Many pathological studies have shown that ASD is frequently associated with grey and white matter changes that can be described by their deviations from
Alexa P Vitins et al.
Archives of toxicology, 88(8), 1573-1588 (2014-02-19)
Liver injury is the leading cause of drug-induced toxicity. For the evaluation of a chemical compound to induce toxicity, in this case steatosis or fatty liver, it is imperative to identify markers reflective of mechanisms and processes induced upon exposure
Yu-Fan Chuang et al.
Biochemical pharmacology, 88(3), 372-383 (2014-02-21)
Inflammation and vascular perturbations are increasingly implicated in the pathogenesis of neurodegenerative diseases. Prevailing evidence suggests that valproic acid (VPA), an antiepileptic and mood stabilizer, exhibits not only neuro-protective effects, but also anti-inflammatory effects in neurodegenerative diseases. However, the underlying
Chi-Tso Chiu et al.
Pharmacological reviews, 65(1), 105-142 (2013-01-10)
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency. The therapeutic potential of
Radu M Nanau et al.
Clinical biochemistry, 46(15), 1323-1338 (2013-06-25)
Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic profiles, as well as a relatively favorable safety profile. However, adverse drug reactions have been reported in relation with
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