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Merck
CN
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文件

安全信息

T8032

Sigma-Aldrich

四环素 盐酸盐

powder

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别名:
Tetracycline HCL
经验公式（希尔记法）:
C22H24N2O8 · HCl
CAS号:
64-75-5
分子量:
480.90
Beilstein:
3844873
EC 号:
200-593-8
MDL编号:
MFCD00078142
UNSPSC代码:
51101500
PubChem化学物质编号:
24900496
NACRES:
NA.76

生物来源

synthetic

质量水平

200

无菌性

γ-irradiated

形式

powder

效能

≥850 μg per mg

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

颜色

faintly yellow to yellow

mp

220-223 °C (lit.)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1

InChI key

XMEVHPAGJVLHIG-FMZCEJRJSA-N

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相关类别

一般描述

Chemical structure: tetracycline

应用

建议以 10-20μg/ml 的量用于分子生物学应用。

生化/生理作用

作用机制：四环素通过细胞膜中的 proin 通道被动扩散，与 30S 核糖体结合，并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合，改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用，这表明起到抗菌作用的是可逆结合的抗生素，而不是不可逆结合的药物。

耐药性机制：这种作用通过细胞壁通透性的丧失而失活。

抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

包装

10MG,20MG

注意

直接在样品瓶中用无菌水 (10mg/ml) 制备储存液。储存液在 2-8°C 下保存不应超过一周；四环素在水溶液中会发生水解。

制备说明

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

其他说明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

警示用语：

Warning

危险分类

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

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Despite high-resolution crystal structures of both inactive and active G protein-coupled receptors (GPCRs), it is still not known how ligands trigger the large structural change on the intracellular side of the receptor since the conformational changes that occur within the
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Split inteins are powerful tools for seamless ligation of synthetic split proteins. Yet, their use remains limited because the already intricate split site identification problem is often complicated by the requirement of extein junction sequences. To address this, we augment
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Fabrication of nanofiber-based drug delivery system with controlled release property is of general interest in biomedical sciences. In this study, we prepared an antibiotic drug tetracycline hydrochloride (TCH)-loaded halloysite nanotubes/poly(lactic-co-glycolic acid) composite nanofibers (TCH/HNTs/PLGA), and evaluated the drug release and
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High-throughput methods, such as ribosome profiling, have revealed the complexity of translation regulation in Bacteria and Eukarya with large-scale effects on cellular functions. In contrast, the translational landscape in Archaea remains mostly unexplored. Here, we developed ribosome profiling in a
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A new spirotetronate-class polyketide, maklamicin (1), was isolated from the culture extract of an endophytic actinomycete of the genus Micromonospora. The structure and relative configuration of 1 were elucidated by interpretation of NMR and other spectroscopic data, and the absolute
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