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Merck
CN

T3383

Sigma-Aldrich

四环素 盐酸盐

≥95% (European Pharmacopoeia HPLC assay)

别名:

4-Epitetracycline hydrochloride, Achromycin hydrochloride

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About This Item

经验公式(希尔记法):
C22H24N2O8 · HCl
CAS号:
分子量:
480.90
Beilstein:
3844873
EC 号:
MDL编号:
UNSPSC代码:
51284043
PubChem化学物质编号:
NACRES:
NA.76

质量水平

检测方案

≥95% (European Pharmacopoeia HPLC assay)

形式

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

yellow

mp

220-223 °C (lit.)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1

InChI key

XMEVHPAGJVLHIG-FMZCEJRJSA-N

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相关类别

一般描述

化学结构:四环素

应用

四环素是一种广谱聚酮类抗生素,在临床上用于治疗细菌感染,例如落基山斑疹热、斑疹伤寒、蜱热、Q 热和 Brill-Zinsser 疾病,并用于治疗上呼吸道感染和痤疮。 它已用于多药耐药性和包括急性胰腺炎在内的潜在副作用的研究。 细胞培养使用浓度推荐为10 mg/L。

生化/生理作用

作用机制:四环素通过细胞膜中的 proin 通道被动扩散,与 30S 核糖体结合,并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合,改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用,这表明起到抗菌作用的是可逆结合的抗生素,而不是不可逆结合的药物。

耐药性机制:这种作用通过细胞壁通透性的丧失而失活。

抗菌谱:包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

注意

该产品应在 0°C 以下冷冻,并避光和防潮。 研究表明,在这些条件下该产品可保持活性 4 年。 储备溶液应储存于 -20°C,并在 37°C 下可稳定保存 4 天。

制备说明

该产品易溶于水,可溶于甲醇和乙醇,但不溶于醚和烃。 该产品在水中经加热产生透明的橙黄色溶液,在 95% 乙醇中,50 mg 溶于 4 mL 溶液中经加热产生透明的黄绿色溶液。 四环素被碱金属氢氧化物溶液迅速破坏,并且由于水解和沉淀,静水溶液变得混浊。 在 pH 低于 2 的溶液中四环素的效力降低。

其他说明

保存于密闭容器内,置于干燥通风处。

警示用语:

Warning

危险分类

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number

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