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安全信息

SYNPLE-P021

Sigma-Aldrich

Reagent-cartridge VHL-PEG1

Synple

别名:

Synple 2

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About This Item

MDL编号:
MFCD32903606
UNSPSC代码:
12161503
NACRES:
NA.22

质量水平

100

参数

up to 0.1 mmol scale

SMILES字符串

[s]1cnc(c1c2ccc(cc2)CNC(=O)[C@H]3N(C[C@@H](C3)O)C(=O)[C@@H](NC(=O)CCOCCC(=O)O)C(C)(C)C)C

InChI

1S/C28H38N4O7S/c1-17-24(40-16-30-17)19-7-5-18(6-8-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)9-11-39-12-10-23(35)36/h5-8,16,20-21,25,33H,9-15H2,1-4H3,(H,29,37)(H,31,34)(H,35,36)/t20-,21+,25-/m1/s1

InChI key

HVPZHRHEHKZOOJ-TYBLODHISA-N

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相关类别

一般描述

Reagent-cartridge VHL-PEG1 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a von Hippel-Lindau (VHL) recruiting ligand ((S,R,S)-AHPC) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol
Linker: PEG1
E3 ligase target and ligand: von Hippel-Lindau (VHL), (S,R,S)-AHPC
Terminal functional group: amine
Compatible substrates: ketone, aldehyde

Cartridge contents:
  • Reducing agent (supported cyanoborohydride)
  • Base (supported triethylamine)
  • SCX (for purification)
  • Degrader building block linker reagent

Related Cartridges:
  • SYNPLE-P001Reagent-cartridge CRBN-PEG1
  • SYNPLE-P002Reagent-cartridge CRBN-PEG2
  • SYNPLE-P003Reagent-cartridge CRBN-PEG3
  • SYNPLE-P004Reagent-cartridge CRBN-PEG4
  • SYNPLE-P005Reagent-cartridge CRBN-PEG5
  • SYNPLE-P022Reagent-cartridge VHL-PEG2
  • SYNPLE-P023Reagent-cartridge VHL-PEG3
  • SYNPLE-P024Reagent-cartridge VHL-PEG4
  • SYNPLE-P025Reagent-cartridge VHL-PEG5

Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks

Features and Benefits of Synple Platform
  • Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization
  • Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
  • Safety - all chemicals are contained in the system, minimizing the user′s exposure
  • Set-up reaction in less than 5 minutes
  • Small footprint
  • Plug & Play system - simple installation
  • Reaction temperatures from 25 °C - 80 °C
  • Cartridges available for many different reactions
  • Prefilled with all required reagents
  • RFID chip containing optimized reaction protocol

其他说明

An integrated console for capsule-based, automated organic synthesis

法律信息

Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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商品

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

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