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SYNPLE-P003

Reagent-cartridge CRBN-PEG3

Synple

别名:

Synple 2

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UNSPSC Code:
12161503
NACRES:
NA.22
MDL number:
MFCD32903606

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SMILES string

[s]1cnc(c1c2ccc(cc2)CNC(=O)[C@H]3N(C[C@@H](C3)O)C(=O)[C@@H](NC(=O)CCOCCC(=O)O)C(C)(C)C)C

InChI

1S/C28H38N4O7S/c1-17-24(40-16-30-17)19-7-5-18(6-8-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)9-11-39-12-10-23(35)36/h5-8,16,20-21,25,33H,9-15H2,1-4H3,(H,29,37)(H,31,34)(H,35,36)/t20-,21+,25-/m1/s1

InChI key

HVPZHRHEHKZOOJ-TYBLODHISA-N

ligand

pomalidomide

Quality Level

100

reaction suitability

reaction type: PROTAC formation

parameter

up to 0.1 mmol scale

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General description

Reagent-cartridge CRBN-PEG3 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol
Linker: PEG3
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: amine
Compatible substrates: ketone, aldehyde

Cartridge contents:
  • Reducing agent (supported cyanoborohydride)
  • Base (supported triethylamine)
  • SCX (for purification)
  • Degrader building block linker reagent

Related Cartridges:
  • SYNPLE-P001Reagent-cartridge CRBN-PEG1
  • SYNPLE-P002Reagent-cartridge CRBN-PEG2
  • SYNPLE-P004Reagent-cartridge CRBN-PEG4
  • SYNPLE-P005Reagent-cartridge CRBN-PEG5
  • SYNPLE-P021Reagent-cartridge VHL-PEG1
  • SYNPLE-P022Reagent-cartridge VHL-PEG2
  • SYNPLE-P023Reagent-cartridge VHL-PEG3
  • SYNPLE-P024Reagent-cartridge VHL-PEG4
  • SYNPLE-P025Reagent-cartridge VHL-PEG5

Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks

Features and Benefits of Synple Platform
  • Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization
  • Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
  • Safety - all chemicals are contained in the system, minimizing the user′s exposure
  • Set-up reaction in less than 5 minutes
  • Small footprint
  • Plug & Play system - simple installation
  • Reaction temperatures from 25 °C - 80 °C
  • Cartridges available for many different reactions
  • Prefilled with all required reagents
  • RFID chip containing optimized reaction protocol

Other Notes

An integrated console for capsule-based, automated organic synthesis

Legal Information

Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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商品

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Synple Automatic Synthesizer & Reagent Cartridges

Discover Synple 2, an automated organic chemical synthesis system that allows researchers to have their products generated for them while reducing both human error and manual labor.

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