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安全信息

SMB01354

Sigma-Aldrich

Losartan carboxylic acid

≥95% (HPLC)

别名:

EXP3174, 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, E-3174, EXP 3174, EXP-3174

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About This Item

经验公式（希尔记法）:
C22H21ClN6O2
CAS号:
124750-92-1
分子量:
436.89
MDL编号:
MFCD00871928
UNSPSC代码:
12352106
NACRES:
NA.21

质量水平

100

方案

≥95% (HPLC)

表单

solid

运输

wet ice

SMILES字符串

Clc1nc([n](c1C(=O)O)Cc2ccc(cc2)c3c(cccc3)c4[nH]nnn4)CCCC

InChI

1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)

InChI key

ZEUXAIYYDDCIRX-UHFFFAOYSA-N

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一般描述

Losartan Carboxylic Acid (E-3174) is an active carboxylic acid metabolite of Losartan. Losartan Carboxylic Acid is a potent and selective angiotensin II receptor type 1 (AT1) antagonist.

应用

Metabolomics research

其他说明

For additional information on our range of Biochemicals, please complete this form.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H317,H360D,H362

危险分类

Lact. - Repr. 1B - Skin Sens. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
SLCN0215

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L L Chang et al.
Journal of medicinal chemistry, 36(17), 2558-2568 (1993-08-20)
A series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones was prepared via several synthetic routes and evaluated as AII receptor antagonists in vitro and in vivo. The preferred compounds contained a [2'-(5-tetrazolyl)biphenyl-4-yl]methyl side chain at N4 and an n-butyl group at C5. A number of
A Gromotowicz-Poplawska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 70(3) (2019-10-01)
The aim of the study was to evaluate the effect of an active metabolite of losartan - EXP3174 - on a performed venous thrombus in hypertensive rat. The contribution of coagulation and fibrinolytic systems as well as platelets in the
Eleni Karatza et al.
Basic & clinical pharmacology & toxicology, 126(3), 193-202 (2019-09-13)
Losartan presents multiple peaks in the concentration-time profile. This characteristic can be attributed to gastric emptying, which is known to significantly affect the disposition of highly soluble and permeable compounds. The aim of this study was to develop a population

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