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检测方案
≥98% (HPLC)
质量水平
形式
solid
溶解性
water: soluble
储存温度
2-8°C
InChI
1S/C6H6O4S.K/c7-11(8,9)10-6-4-2-1-3-5-6;/h1-5H,(H,7,8,9);/q;+1/p-1
InChI key
NOUFXYHWAWIDNT-UHFFFAOYSA-M
一般描述
Potassium phenyl sulfate is the salt of gut metabolite phenol sulfate.It is biosynthesized from phenol and phosphoadenosine phosphosulfate through the action of the enzyme sulfotransferase 1A1 in the liver. Also, it induces reactive oxygen species (ROS) production and decreases glutathione levels, rendering cells vulnerable to oxidative stress.
应用
Metabolomics research
Microbiome research
Microbiome research
其他说明
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Takeo Edamatsu et al.
PloS one, 13(2), e0193342-e0193342 (2018-02-24)
In chronic kidney disease patients, oxidative stress is generally associated with disease progression and pathogenesis of its comorbidities. Phenyl sulfate is a protein-bound uremic solute, which accumulates in chronic kidney disease patients, but little is known about its nature. Although
Koichi Kikuchi et al.
Nature communications, 10(1), 1835-1835 (2019-04-25)
Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in
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