推荐产品
生物来源
microbial
检测方案
≥90%
形式
liquid
浓度
100 mg/mL in water
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
neoplastics
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
−20°C
相关类别
一般描述
Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic commonly derived from Streptomyces Sp. It exerts its antibacterial activity by inhibiting Topo II α, which corresponds to bacterial DNA gyrase. It is effective against both gram-positive and gram-negative bacteria and is significant in research involving highly beta-lactam-resistant pneumococcal infections and anti-orthopoxvirus applications. Functioning as a competitive inhibitor in the ATPase reaction catalyzed by GyrB, Novobiocin is employed in microbiology and cell biology research to effectively prevent the growth of bacterial contaminants.
应用
Novobiocin has been used:
- in cell culture systems to treat mycoplasma contaminations.[3]
- in a research to where it has exhibited anti-cancer effects by inhibition of Hsp90 (heat shock protein)[4],[5]
生化/生理作用
Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II
Activity spectrum: Active against gram-positive and gram-negative bacteria
Activity spectrum: Active against gram-positive and gram-negative bacteria
特点和优势
- Ready available solution reduce the need for preparation time
- Commonly used in Cell Biology and Biochemical applications
- High quality antibiotic suitable for mulitple research applications
制备说明
Novobiocin Ready Made Solution is light sensitive. Thaw this product at room temperature. It is recommended to avoid repeated freeze thaw cycles of this product. The suggested concentration of Novobiocin for cell culture assays is 50-1000 μg/mL,,, therefore, it is recommended to dilute the Ready Made Solution 1:100-2000.
其他说明
For additional information on our range of Biochemicals, please complete this form.
警示用语:
Warning
危险声明
危险分类
Skin Sens. 1
WGK
WGK 1
法规信息
监管及禁止进口产品
Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth.
Antimicrobial Agents and Chemotherapy, 22, 662-671 (1982)
Environmentally constrained mutation and adaptive evolution in Salmonella.
Current Biology, 9, 1477-1481 (1999)
Mycoplasmas in tissue culture.
Journal of Cell Science, 1, 145-168 (1966)
Biosynthesis of novobiocin by Streptomyces niveus.
Antimicrobial Agents and Chemotherapy, 1, 123-134 (1972)
Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors.
Bioorganic & Medicinal Chemistry Letters, 21, 7170-7174 (2011)
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