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Merck
CN

S1100000

螺旋霉素

European Pharmacopoeia (EP) Reference Standard

别名:

Formacidine

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化学文摘社编号:
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI key

ACTOXUHEUCPTEW-JMRHEKERSA-N

SMILES string

CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](OC2CCC(C(C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C

InChI

1S/C43H74N2O14/c1-24-21-29(19-20-46)39(59-42-37(49)36(45(9)10)38(27(4)56-42)58-35-23-43(6,51)41(50)28(5)55-35)40(52-11)31(47)22-33(48)53-25(2)15-13-12-14-16-32(24)57-34-18-17-30(44(7)8)26(3)54-34/h12-14,16,20,24-32,34-42,47,49-51H,15,17-19,21-23H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,28?,29+,30?,31-,32+,34?,35?,36?,37?,38?,39+,40+,41?,42?,43?/m1/s1

grade

pharmaceutical primary standard

API family

spiramycin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Spiramycin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Halitosis and weight loss in a cat.
Genaro A Coria-Avila et al.
Lab animal, 39(6), 169-170 (2010-05-21)
Sharon M Weinstein et al.
Journal of pain and symptom management, 43(4), 679-693 (2011-10-11)
Neuropathic pain in patients with cancer can be difficult to treat effectively. The purpose of the study was to determine safety and efficacy of KRN5500, a novel, spicamycin-derived, nonopioid analgesic agent, in patients with advanced cancer and neuropathic pain of
L Mandelbrot
Gynecologie, obstetrique & fertilite, 40(10), 591-598 (2012-09-18)
In France, screening for toxoplasmosis is mandatory during pregnancy, whereas it is not performed in most other countries. The rationale for prenatal screening is to allow for several levels of intervention: primary prevention by health education; in case of seroconversion
Thomas E Rams et al.
Anaerobe, 17(4), 201-205 (2011-04-29)
The occurrence of in vitro resistance to therapeutic concentrations of spiramycin, amoxicillin, and metronidazole was determined for putative periodontal pathogens isolated in the United States. Subgingival plaque specimens from 37 consecutive adults with untreated severe periodontitis were anaerobically cultured, and
Hoang Chuong Nguyen et al.
Antimicrobial agents and chemotherapy, 54(7), 2830-2839 (2010-05-05)
Streptomyces ambofaciens synthesizes spiramycin, a 16-membered macrolide antibiotic used in human medicine. The spiramycin molecule consists of a polyketide lactone ring (platenolide) synthesized by a type I polyketide synthase, to which three deoxyhexoses (mycaminose, forosamine, and mycarose) are attached successively

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