S100
米赛林 盐酸盐
analytical standard, for drug analysis
别名:
1,2,3,4,10,14b-六氢-2-甲基-二苯并[c,f]吡嗪并[1,2-a]氮杂卓 盐酸盐
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经验公式（希尔记法）:
C18H20N2 · HCl
化学文摘社编号:
分子量:
300.83
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
244-426-7
MDL number:
InChI key
YNPFMWCWRVTGKJ-UHFFFAOYSA-N
InChI
1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
SMILES string
Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
solubility
H2O: 3.4 mg/mL, ethanol: 5.6 mg/mL
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Antidepressant; antagonist/inverse agonist at 5-HT2 serotonin receptors; also blocks the H1 histamine receptor and the α2 adrenoceptor.
Yun Gu et al.
Frontiers in pharmacology, 9, 1026-1026 (2018-10-26)
Remyelination is critical for nerve regeneration. However, the molecular mechanism involved in remyelination is poorly understood. To explore the roles of 17β-estradiol (E2) for myelination in the peripheral nervous system, we used a co-culture model of rat dorsal root ganglion
A C de Luca et al.
Journal of tissue engineering and regenerative medicine, 12(3), 676-686 (2017-05-31)
Adipose-derived stem cells (ASC) are becoming one of the most exploited cells in peripheral nerve repair. They are fast-growing and able to protect neurons from apoptosis; they can reduce post-injury latency and the risk of muscle atrophy. This study evaluates
Marike van Lingen et al.
Frontiers in cell and developmental biology, 7, 65-65 (2019-05-21)
Serotonin (5-HT) is a crucial signal in the neurogenic niche microenvironment. Dysregulation of the 5-HT system leads to mood disorders but also to changes in appetite and metabolic rate. Tryptophan hydroxylase 2-deficient (Tph2-/- ) mice depleted of brain 5-HT display
Boaz Barak et al.
Nature neuroscience, 22(5), 700-708 (2019-04-24)
Williams syndrome (WS), caused by a heterozygous microdeletion on chromosome 7q11.23, is a neurodevelopmental disorder characterized by hypersociability and neurocognitive abnormalities. Of the deleted genes, general transcription factor IIi (Gtf2i) has been linked to hypersociability in WS, although the underlying
Steven M Graves et al.
Pharmacology & therapeutics, 136(3), 343-353 (2012-09-11)
Understanding substance use disorders (SUDs) and the problems associated with abstinence has grown in recent years. Nonetheless, highly efficacious treatment targeting relapse prevention has remained elusive, and there remains no FDA-approved pharmacotherapy for psychostimulant dependence. Preclinical and clinical investigations assessing
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