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Merck
CN

S0252

Sigma-Aldrich

磺溴酞 二钠盐 水合物

used to study hepatocyte transport functions

别名:

BSP, 溴磺胺钠 二钠盐 水合物

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About This Item

经验公式(希尔记法):
C20H8Br4Na2O10S2 · xH2O
分子量:
838.00 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47

质量水平

表单

powder

组成

Water (by Karl Fischer): ≤ 8%

Sodium (Na) anhydrous: 4.6-5.8%

技术

titration: suitable

颜色

white to light gray

溶解性

water: 50 mg/mL, clear to hazy

λmax

575-581 nm

应用

diagnostic assay manufacturing
hematology
histology

储存温度

room temp

SMILES字符串

[Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O

InChI

1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2

InChI key

CDTNUNQQEUGDSD-UHFFFAOYSA-L

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应用

磺溴酞二钠盐水合物已用作阳性对照,以研究11-酮-β-乳香酸(KBA)和3-乙酰基-11-酮-β-乳香酸(AKBA)与有机阴离子转运蛋白OATP1B3的相互作用。

生化/生理作用

磺溴酞(BSP)是有机阴离子转运多肽(OATP)的高亲和力有机离子底物,已被用作多药耐药相关蛋白2(Mrp2)的底物。BSP通过OATP转运到肝细胞中,与谷胱甘肽结合后,通过MRP2排泄到胆汁中。发现它抑制醛酮还原酶ARK1C20。

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Jing-Dong Zhou et al.
Journal of cellular and molecular medicine, 21(8), 1468-1481 (2017-04-30)
Promoter hypermethylation-mediated inactivation of ID4 plays a crucial role in the development of solid tumours. This study aimed to investigate ID4 methylation and its clinical relevance in myeloid malignancies. ID4 hypermethylation was associated with higher IPSS scores, but was not
Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1).
Visentin M
Molecular Pharmaceutics, 81(2), 134-142 (2012)
Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats.
Xenobiotica, 42(8) (2012)
Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2
Philip Kruger
European Journal of Pharmaceutical Sciences, 36 (2009)
Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3- Exchange*
Lisa M
The Journal of Biological Chemistry (1997)

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