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质量水平
表单
powder
组成
Water (by Karl Fischer): ≤ 8%
Sodium (Na) anhydrous: 4.6-5.8%
技术
titration: suitable
颜色
white to light gray
溶解性
water: 50 mg/mL, clear to hazy
λmax
575-581 nm
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
[Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O
InChI
1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2
InChI key
CDTNUNQQEUGDSD-UHFFFAOYSA-L
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应用
磺溴酞二钠盐水合物已用作阳性对照,以研究11-酮-β-乳香酸(KBA)和3-乙酰基-11-酮-β-乳香酸(AKBA)与有机阴离子转运蛋白OATP1B3的相互作用。
生化/生理作用
磺溴酞(BSP)是有机阴离子转运多肽(OATP)的高亲和力有机离子底物,已被用作多药耐药相关蛋白2(Mrp2)的底物。BSP通过OATP转运到肝细胞中,与谷胱甘肽结合后,通过MRP2排泄到胆汁中。发现它抑制醛酮还原酶ARK1C20。
警示用语:
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Journal of cellular and molecular medicine, 21(8), 1468-1481 (2017-04-30)
Promoter hypermethylation-mediated inactivation of ID4 plays a crucial role in the development of solid tumours. This study aimed to investigate ID4 methylation and its clinical relevance in myeloid malignancies. ID4 hypermethylation was associated with higher IPSS scores, but was not
Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1).
Molecular Pharmaceutics, 81(2), 134-142 (2012)
Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats.
Xenobiotica, 42(8) (2012)
Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2
European Journal of Pharmaceutical Sciences, 36 (2009)
Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3- Exchange*
The Journal of Biological Chemistry (1997)
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