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经验公式(希尔记法):
C17H20N4O6
化学文摘社编号:
分子量:
376.36
NACRES:
NA.21
PubChem Substance ID:
eCl@ss:
34058005
UNSPSC Code:
12352205
EC Number:
201-507-1
MDL number:
Beilstein/REAXYS Number:
97825
产品名称
(−)-核黄素, meets USP testing specifications
InChI key
AUNGANRZJHBGPY-SCRDCRAPSA-N
InChI
1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1
SMILES string
CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1
agency
USP/NF
meets USP testing specifications
assay
98.0-102.0% dry basis
form
powder
color
dark yellow
mp
290 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
Quality Level
Application
使用(-)-核黄素通过紫外线A (UVA)激活法研究其在体外的抗菌作用。它也被用于交联星形胶质细胞的聚乙烯膜表面的胶原涂层。
Biochem/physiol Actions
核黄素是活性酶辅因子核黄素5′- 单磷酸盐(也称为黄素单核苷酸或FMN)和黄素腺嘌呤二核苷酸(FAD)的前体。饮食中的核黄素缺乏会导致一种定义明确的综合症,称为核黄素缺乏症,核黄素对肿瘤生长和心血管疾病具有抑制作用。它的缺乏常常影响涉及氧化还原反应的代谢。核黄素对于铁吸收、胃肠道发育、神经发生、角膜血管化和角膜混浊至关重要。
General description
核黄素是一种可溶于水的必要维生素。牛奶和鸡蛋是它的主要来源。核黄素通常与所有组织中的酶结合。核黄素在血浆中定位时,会与白蛋白和特异性免疫球蛋白结合。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
N Kotowicz et al.
Beneficial microbes, 10(7), 759-771 (2020-01-23)
Bacillus species are becoming increasingly relevant for use as probiotics or feed additives where their heat stability can ensure survival in the food matrix or enable long-term storage at ambient temperature. Some Bacillus species are pigmented and in this study
The efficiency of cross-linking methods in eradication of bacteria is influenced by the riboflavin concentration and the irradiation time of ultraviolet light
Backman A, et al.
Acta Ophthalmologica, 92(7), 656-661 (2014)
Photochemical eradication of methicillin-resistant Staphylococcus aureus by blue light activation of riboflavin
Makdoumi K, et al.
Acta Ophthalmologica, 95(5), 498-502 (2017)
Mechanical stretching elevates peptidyl arginine deiminase 2 expression in astrocytes
Algeciras ME, et al.
Current Eye Research, 33(11-12), 994-1001 (2008)
Graciely Gomes Correa et al.
Data in brief, 31, 105736-105736 (2020-06-09)
Modular and tuneable genetic tools for Metabolic Engineering fuels the development of chassis for the efficient production of biocompounds at industrial scale. We have constructed an autoinduction device for gene expression in Bacillus subtilis based on the LuxR/I quorum sensing
商品
Riboflavin's impact on cell culture systems for manufacturing proteins and monoclonal antibodies discussed.
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