R7649
(−)-核黄素
meets USP testing specifications
别名:
乳黄素, 维生素 B2, 维生素 G
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关于此项目
经验公式（希尔记法）:
C17H20N4O6
化学文摘社编号:
分子量:
376.36
NACRES:
NA.21
PubChem Substance ID:
eCl@ss:
34058005
UNSPSC Code:
12352205
EC Number:
201-507-1
MDL number:
Beilstein/REAXYS Number:
97825
产品名称
(−)-核黄素, meets USP testing specifications
InChI key
AUNGANRZJHBGPY-SCRDCRAPSA-N
InChI
1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1
SMILES string
CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1
agency
USP/NF
meets USP testing specifications
assay
98.0-102.0% dry basis
form
powder
color
dark yellow
mp
290 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
Quality Level
Application
使用(-)-核黄素通过紫外线A (UVA)激活法研究其在体外的抗菌作用。它也被用于交联星形胶质细胞的聚乙烯膜表面的胶原涂层。
Biochem/physiol Actions
核黄素是活性酶辅因子核黄素5′- 单磷酸盐（也称为黄素单核苷酸或FMN）和黄素腺嘌呤二核苷酸(FAD)的前体。饮食中的核黄素缺乏会导致一种定义明确的综合症，称为核黄素缺乏症，核黄素对肿瘤生长和心血管疾病具有抑制作用。它的缺乏常常影响涉及氧化还原反应的代谢。核黄素对于铁吸收、胃肠道发育、神经发生、角膜血管化和角膜混浊至关重要。
General description
核黄素是一种可溶于水的必要维生素。牛奶和鸡蛋是它的主要来源。核黄素通常与所有组织中的酶结合。核黄素在血浆中定位时，会与白蛋白和特异性免疫球蛋白结合。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
N Kotowicz et al.
Beneficial microbes, 10(7), 759-771 (2020-01-23)
Bacillus species are becoming increasingly relevant for use as probiotics or feed additives where their heat stability can ensure survival in the food matrix or enable long-term storage at ambient temperature. Some Bacillus species are pigmented and in this study
Bas Berbers et al.
Scientific reports, 10(1), 4310-4310 (2020-03-11)
Antimicrobial resistance (AMR) is a major public health threat. Plasmids are able to transfer AMR genes among bacterial isolates. Whole genome sequencing (WGS) is a powerful tool to monitor AMR determinants. However, plasmids are difficult to reconstruct from WGS data.
The efficiency of cross-linking methods in eradication of bacteria is influenced by the riboflavin concentration and the irradiation time of ultraviolet light
Backman A, et al.
Acta Ophthalmologica, 92(7), 656-661 (2014)
Evaluation of antibacterial efficacy of photo-activated riboflavin using ultraviolet light (UVA)
Makdoumi K, et al.
Graefe'S Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 248(2), 207-212 (2010)
Photochemical eradication of methicillin-resistant Staphylococcus aureus by blue light activation of riboflavin
Makdoumi K, et al.
Acta Ophthalmologica, 95(5), 498-502 (2017)
商品
Riboflavin's impact on cell culture systems for manufacturing proteins and monoclonal antibodies discussed.
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