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Merck
CN

PHR2438

4,7-二氯喹啉

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

4,7-Dichloroquinoline

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关于此项目

经验公式（希尔记法）:
C9H5Cl2N
化学文摘社编号:
86-98-6
分子量:
198.05
NACRES:
NA.24
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
125359
MDL number:
MFCD00006774

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产品名称

4,7-二氯喹啉, Pharmaceutical Secondary Standard; Certified Reference Material

SMILES string

Clc1ccc2c(Cl)ccnc2c1

InChI key

HXEWMTXDBOQQKO-UHFFFAOYSA-N

InChI

1S/C9H5Cl2N/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-5H

biological source

synthetic

grade

certified reference material
pharmaceutical secondary standard

agency

EP
USP
traceable to USP 1118328

vapor pressure

0.0000811 kPa ( 25 °C)

API family

chloroquine

form

crystalline

packaging

pkg of 50 mg

color

white to brown

pH

3.86 (24.9 °C)

bp

298.4 °F (148°C)

mp

81-83 °C (lit.)

solubility

water: slightly soluble 0.037 g/L at 25 °C
ethanol: freely soluble
ether: freely soluble

density

1.31 g/cm3 at 20 °C (971.4 hPa)

application(s)

pharmaceutical

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Chloroquine Related Compound A can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography (LC) technique.
Chloroquine Related Compound A can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography (LC) technique.

General description

Chloroquine Related Compound A is an impurity of chloroquine, a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC4608 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Chloroquine Phosphate USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Vincent MJ, et al.
Virology Journal, 2(1), 1-10 (2005)

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