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Merck
CN

PHR2077

Supelco

利塞膦酸盐相关化合物C

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
2-(3-Pyridinyl)ethylidene]bis(phosphonic acid), 2-(Pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
经验公式(希尔记法):
C7H11NO6P2
CAS号:
分子量:
267.11
Beilstein:
9562253
MDL编号:
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to Ph. Eur. Y0001540
traceable to USP 1604643

API类

risedronate

CofA

current certificate can be downloaded

包装

pkg of 50 mg

应用

pharmaceutical

格式

neat

储存温度

2-30°C

SMILES字符串

OP(O)(C(CC1=CN=CC=C1)P(O)(O)=O)=O

InChI

1S/C7H11NO6P2/c9-15(10,11)7(16(12,13)14)4-6-2-1-3-8-5-6/h1-3,5,7H,4H2,(H2,9,10,11)(H2,12,13,14)

InChI key

KZMOFWIRXNQJET-UHFFFAOYSA-N

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一般描述

Risedronate Related Compound C is an impurity of risedronate, belonging to the group of pyridinyl bisphosphonates, and is effectively used in the treatment of Paget′s disease of bone. It is also used for the treatment of skeletal disorders since it inhibits osteoclast-mediated bone resorption and modulates bone metabolism.

应用

Risedronate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase ion-pair high-performance liquid chromatographic method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB8927 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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Stability indicating ion?pair HPLC method for the determination of risedronate in a commercial formulation
Aluoch A, et al.
Journal of Liquid Chromatography and Related Technologies, 27(17), 2799-2813 (2004)
Development and validation of a reversed-phase ion-pair high-performance liquid chromatographic method for the determination of risedronate in pharmaceutical preparations
Kyriakides D and Panderi I
Analytica Chimica Acta, 584(1), 153-159 (2007)

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