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Merck
CN

PHR2025

Supelco

去苄基多奈哌齐盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
5,6-Dimethoxy-2-(piperidin-4-ylmethyl)indan-1-one hydrochloride
经验公式(希尔记法):
C17H23NO3 · HCl
分子量:
325.83
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1171819

API类

donepezil

CofA

current certificate can be downloaded

包装

pkg of 50 mg

应用

pharmaceutical

格式

neat

储存温度

2-8°C

InChI

1S/C17H23NO3.ClH/c1-20-15-9-12-8-13(7-11-3-5-18-6-4-11)17(19)14(12)10-16(15)21-2;/h9-11,13,18H,3-8H2,1-2H3;1H

InChI key

WOZXDQQCMZIQEG-UHFFFAOYSA-N

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一般描述

Desbenzyl donepezil hydrochloride is a metabolite of drug, donepezil hydrochloride. Donepezil hydrochloride is a neurocognition-enhancing drug prescribed especially to manage dementia during Alzheimer′s disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Donepezil hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB4752 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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访问文档库

Donepezil for dementia due to Alzheimer's disease
Birks JS and Harvey RJ
Cochrane database of systematic reviews (Online) (2018)
RP-HPLC method for the estimation of donepezil hydrochloride dosage form
Barot TG and Patel PK
Journal of Chemistry, 6(2), 594-600 (2009)
Determination of donepezil hydrochloride in human plasma and pharmaceutical formulations by HPLC with fluorescence detection
Abonassif M, et al
Acta pharmaceutica, 61(4), 403-413 (2011)
A new HPLC method to determine Donepezil hydrochloride in tablets.
Pappa H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 27(1-2), 177-182 (2002)

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