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Merck
CN

PHR1875

Supelco

缬沙坦相关化合物A

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

D-Valsartan, N-VALERYL-N-{[2’-(1HTETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-D-VALINE(ent-Valsartan), (R)-N-Valeryl-N-([2′-(1H-tetrazole-5-yl)-biphenyl-4-yl]methyl)valine, N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-D-valine

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About This Item

经验公式(希尔记法):
C24H29N5O3
分子量:
435.52
MDL编号:
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1708773

API类

valsartan

CofA

current certificate can be downloaded

包装

pkg of 30 mg

应用

pharmaceutical small molecule

格式

neat

储存温度

2-8°C

SMILES字符串

CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@H](C(C)C)C(O)=O

InChI

1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m1/s1

InChI key

ACWBQPMHZXGDFX-JOCHJYFZSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Valsartan Related Compound A is an impurity of valsartan, an orally active specific angiotensin II receptor blocker or angiotensin-II antagonist, which is widely used in treating hypertension by lowering the blood pressure.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Valsartan may be used as a pharmaceutical reference standard for the determination of the analyte in tablet formulations, bulk and pharmaceutical dosage forms using reversed-phase high-performance liquid chromatography technique.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAB1041 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazardExclamation mark

警示用语:

Warning

危险声明

危险分类

Repr. 2 - STOT SE 3

靶器官

Central nervous system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

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访问文档库

Validated RP-HPLC method for the quantitative estimation of valsartan in bulk and pharmaceutical dosage forms
Thanusha G, et al.
International Journal of ChemTech Research, 2(2), 1194-1198 (2010)
Simultaneous determination of valsartan and hydrochlorothiazide in tablets by RP-HPLC
Tian FD, et al.
Indian Journal of Pharmaceutical Sciences, 70(3), 372-372 (2008)

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