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Merck
CN

PHR1773

雷尼替丁相关化合物A

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

2-{{{5-[(Dimethylamino)methyl]furan-2-yl}methyl}sulfanyl}ethanamine hemifumarate salt, 2-{{{5-[(DIMETHYLAMINO)METHYL] FURAN-2-YL}METHYL}SULFANYL} ETHANEAMINEHEMIFUMARATE SALT, Ranitidine Impurity B, 2-{{{5-[(Dimethylamino)methyl]-2-furanyl}methyl}thio}ethylamine hemifumarate salt, 5-{[(2-Aminoethyl)thio]methyl}-N,N-dimethyl- 2-furanmethanamine hemifumarate salt, Ranitidine diamine hemifumarate salt

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关于此项目

经验公式（希尔记法）:
C10H18N2OS · 0.5 C4H4O4
化学文摘社编号:
91224-69-0
分子量:
272.36
UNSPSC Code:
41116107
NACRES:
NA.24

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产品名称

雷尼替丁相关化合物A, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C10H18N2OS.C4H4O4/c1-12(2)7-9-3-4-10(13-9)8-14-6-5-11;5-3(6)1-2-4(7)8/h3-4H,5-8,11H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key

VKUKMWIQZWDCGK-WLHGVMLRSA-N

SMILES string

OC(=O)\C=C\C(O)=O.CN(C)Cc1ccc(CSCCN)o1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1598507

API family

ranitidine

CofA

current certificate can be downloaded

packaging

pkg of 100 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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相关类别

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Ranitidine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using kinetic spectrophotometric technique and electrochemical method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ranitidine Related Compound A is an impurity of ranitidine, an inhibitor of gastric acid secretion. Ranitidine is widely used for treating gastric and duodenal ulcers.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0714 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly (chromotrope 2B) modified activated glassy carbon electrodes
Li X and Xu G
Journal of food and drug analysis, 22(3), 345-349 (2014)
Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations
Hassan ME and Belal F
Journal of Pharmaceutical and Biomedical Analysis, 27(1-2), 31-38 (2002)

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