PHR1772
美罗培南三水合物
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
(1R,5S,6S)-2-[(3S,5S)-5-（二甲氨基羰基）吡咯烷-3-基硫]-6-\ [( R )-1-羟乙基]-1-甲基碳青霉烯-2-烯-3-羧酸三水合物
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关于此项目
经验公式（希尔记法）:
C17H25N3O5S · 3H2O
化学文摘社编号:
分子量:
437.51
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
美罗培南三水合物, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1
SMILES string
O.O.O.C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N2C1=O)C(O)=O
InChI key
CTUAQTBUVLKNDJ-OBZXMJSBSA-N
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0001252
traceable to USP 1392454
API family
meropenem
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Biochem/physiol Actions
美罗培南三水合物是一种对革兰阳性菌和革兰阴性菌均有活性的超广谱 β-内酰胺类抗生素。
美罗培南三水合物是一种超广谱 β-内酰胺类抗生素。
Application
Lincomycin Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and peritoneal dialysis solution by spectrophotometric and various chromatography techniques.(58)
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Meropenem belongs to the class of a semi-synthetic 1β-methylcarbapenem antibiotics. It shows an extremely broad-spectrum of antibacterial performance and is known for its high stability against renal dehydropeptidase-I (DHP-I).
Meropenem belongs to the class of a semi-synthetic 1β-methylcarbapenem antibiotics. It shows an extremely broad-spectrum of antibacterial performance and is known for its high stability against renal dehydropeptidase-I (DHP-I).
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7853 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Stability of amoxycillin, clindamycin and meropenem in peritoneal dialysis solution.
Tran MD, et al.
Journal of Pharmacy Practice and Research, 42(3), 218-222 (2012)
Ultraviolet spectrophotometry (dual wavelength and chemometric) and high performance liquid chromatography for simultaneous estimation of meropenem and sulbactam sodium in pharmaceutical dosage form.
Marwada KR, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 124(3), 292-299 (2014)
Chromatographic determination of polymerized impurities in meropenem.
Cai SY and Hu CQ
Journal of Pharmaceutical and Biomedical Analysis, 37(3), 585-589 (2005)
Youngchang Kim et al.
Protein science : a publication of the Protein Society, 29(3), 723-743 (2019-12-18)
Emergence of Enterobacteriaceae harboring metallo-β-lactamases (MBL) has raised global threats due to their broad antibiotic resistance profiles and the lack of effective inhibitors against them. We have been studied one of the emerging environmental MBL, the L1 from Stenotrophomonas maltophilia
Geertrui Rasschaert et al.
Antibiotics (Basel, Switzerland), 9(1) (2020-01-23)
Pig manure may contain antibiotic residues, antibiotic-resistant bacteria or pathogens, which may reach the environment upon fertilization. During this study, 69 antibiotic residues belonging to 12 classes were quantified in 89 pig slurry samples. These samples were also studied for
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