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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to USP 1302101
API类
guanfacine
CofA
current certificate can be downloaded
包装
pkg of 500 mg
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl
InChI
1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
InChI key
DGFYECXYGUIODH-UHFFFAOYSA-N
基因信息
human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
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相关类别
一般描述
Guanfacine hydrochloride, is a selective α-adrenergic receptor agonist, that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
Guanfacine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
生化/生理作用
α-2 noradrenergic receptor agonist.
分析说明
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAC3708 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
推荐产品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods
Wahbi AM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 11(8), 639- 645 (1993)
L A Cornish
Clinical pharmacy, 7(3), 187-197 (1988-03-01)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of guanfacine hydrochloride are reviewed. Guanfacine lowers blood pressure by activating CNS alpha adrenoreceptors, which results in sympathetic outflow leading to reduced vascular tone. However, initial hypotensive response to guanfacine may
Guanfacine and secondary mania in children
Horrigan JP and Barnhill LJ
Journal of Affective Disorders, 54(3), 309- 314 (1999)
Guanfacine hydrochloride
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 45(3), 2133-2133 (2018)
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