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Merck
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文件

安全信息

PHR1732

Supelco

盐酸万古霉素

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
Vancomycin 盐酸盐
经验公式（希尔记法）:
C66H75Cl2N9O24 · xHCl
CAS号:
1404-93-9
分子量:
1449.25 (free base basis)
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. V0045000
traceable to USP 1709007

API类

vancomycin

CofA

current certificate can be downloaded

包装

pkg of 4x250 mg

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

-10 to -25°C

InChI

1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1

InChI key

LCTORFDMHNKUSG-XTTLPDOESA-N

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Vancomycin hydrochloride is a glycopeptide antibiotic, effective for the treatment of endocarditis caused by Gram-positive bacteria. It is used to inhibit the synthesis of bacterial cell wall and prevents the synthesis of peptidoglycan by binding tightly to peptides containing D-alanyl-D-alanine at the free carboxyl end. It is isolated from both Streotomyces orientalis and Nocardia lurida.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Vancomycin hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, pure form and injections preparations using high-performance liquid chromatography technique and spectrophotometric technique.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC0718 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317,H334

危险分类

Resp. Sens. 1 - Skin Sens. 1

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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James Shaw et al.
Journal of orthopaedic trauma, 34(4), e109-e113 (2020-03-21)
Prefabrication and storage of antibiotic beads may decrease surgical time and allow for use in other settings. This study investigated the effects of sterilization technique and storage time on the bioactivity of antibiotic polymethyl methacrylate (PMMA) beads. Uniform beads of
Development and validation of high-performance liquid chromatographic method for the simultaneous determination of ceftriaxone and vancomycin in pharmaceutical formulations and biological samples
Tariq A, et al.
ScienceAsia, 36(4), 297-304 (2010)
Flow Injection-Spectrophotometric Determination of Vancomycin Hydrochloride in Pharmaceutical Preparations Using Diazotized Metoclopramide
Al-Abachi QM, et al.
Journal of Al-Nahrain University, 18(1), 9-19 (2015)
Andrés Aranda-Díaz et al.
eLife, 9 (2020-01-30)
Predicting antibiotic efficacy within microbial communities remains highly challenging. Interspecies interactions can impact antibiotic activity through many mechanisms, including alterations to bacterial physiology. Here, we studied synthetic communities constructed from the core members of the fruit fly gut microbiota. Co-culturing
Melinda A Engevik et al.
Gut microbes, 13(1), 1-21 (2021-05-15)
Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can beneficially modulate mucin production, little work has been done investigating the effects of Bifidobacterium on goblet
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