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Merck
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主要文件

安全信息

PHR1686

Supelco

Tazobactam

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Tazobactam, (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo-[3.2.0]heptanes-2-carboxylicacid-4,4-dioxide, [2S-(2α,3β,5α)]-3-Methyl-7-oxo-3-(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsäure-4,4-dioxid

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About This Item

经验公式（希尔记法）:
C10H12N4O5S
CAS号:
89786-04-9
分子量:
300.29
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1643383

API类

tazobactam

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

[S]1(=O)(=O)[C@H]2N([C@H]([C@@]1(C[n]3nncc3)C)C(=O)O)C(=O)C2

InChI

1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1

InChI key

LPQZKKCYTLCDGQ-WEDXCCLWSA-N

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一般描述

Tazobactam is a penicillanic acid sulfone used in combination with β-lactamase antibiotic as antibacterial to reduce the development of drug-resistant bacteria.

应用

Tazobactam may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA6302 in the slot below. This is an example certificate only and may not be the lot that you receive.

相关产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7(9), 127-131 (2019)
Simultaneous determination of piperacillin and tazobactam in pharmaceutical formulations by RP-HPLC method
Veni KRP, et al.
Journal of Pharmacy Research, 7(1), 127-131 (2013)
Emily Marsh et al.
Clinica chimica acta; international journal of clinical chemistry, 486, 265-268 (2018-08-18)
Therapeutic drug monitoring is used for aminoglycosides and vancomycin, and has been proposed for β-lactam antibiotics. Clinical blood samples in the ICU are often obtained via an existing vascular catheter rather than fresh needle phlebotomy. If antibiotics had previously been

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