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Merck
CN

PHR1673

Supelco

利多卡因相关化合物H

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
N-(2,6-二甲基苯基)氯乙酰胺, 1-氯乙酰氨基-2,6-二甲苯, 2-Chloro-2′,6′-acetoxylidide, 2-氯-2′,6′-二甲基乙酰苯胺, 2-氯-N-(2,6-二甲基苯基)乙酰胺, N-(2,6-二甲基苯基)-2-氯乙酰胺, N-(2,6-二甲苯基)氯乙酰胺, N-氯乙酰基-2,6-二甲基苯胺, 氯乙酰氨基-2,6-二甲苯胺
线性分子式:
ClCH2CONHC6H3(CH3)2
CAS号:
分子量:
197.66
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1366080

API类

lidocaine

CofA

current certificate can be downloaded

包装

pkg of 100 mg

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

150-151 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

Cc1cccc(C)c1NC(=O)CCl

InChI

1S/C10H12ClNO/c1-7-4-3-5-8(2)10(7)12-9(13)6-11/h3-5H,6H2,1-2H3,(H,12,13)

InChI key

FPQQSNUTBWFFLB-UHFFFAOYSA-N

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一般描述

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Lidocaine Related Compound H is one of the impurities of the local anesthetic lidocaine found in bulk powder and dosage forms.

应用

This pharmaceutical secondary standard can also be used as follows:

  • Simultaneous estimation of lidocaine hydrochloride, tribenoside, and their related compounds in pharmaceutical formulations by high-performance liquid chromatography (HPLC) combined with a UV/Vis detector
  • Multi-analysis of dexpanthenol, lidocaine hydrochloride, mepyramine maleate, and their related impurities in their combined dosage forms by high-performance liquid chromatography (HPLC)-diode array detection
  • Development of an HPLC method for the estimation of three active pharmaceutical ingredients along with their impurities in a semi-solid topical formulation

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC2078 in the slot below. This is an example certificate only and may not be the lot that you receive.

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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说明
价格

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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Alina Plenis et al.
Chromatographia, 76(5-6), 255-265 (2013-03-14)
A new liquid chromatographic (LC) method for simultaneous determination of lidocaine hydrochloride (LH) and tribenoside (TR) along with their related compounds in pharmaceutical preparations is described. Satisfactory LC separation of all analytes after the liquid-liquid extraction (LLE) procedure with ethanol

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