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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to Ph. Eur. Y0001575
蒸汽压
<0.01 mmHg ( 20 °C)
API类
lidocaine
CofA
current certificate can be downloaded
包装
pkg of 100 mg
技术
HPLC: suitable
gas chromatography (GC): suitable
折射率
n20/D 1.560 (lit.)
沸点
214 °C/739 mmHg (lit.)
mp
10-12 °C (lit.)
密度
0.984 g/mL at 25 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
Cc1cccc(C)c1N
InChI
1S/C8H11N/c1-6-4-3-5-7(2)8(6)9/h3-5H,9H2,1-2H3
InChI key
UFFBMTHBGFGIHF-UHFFFAOYSA-N
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一般描述
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
The standard is a certified reference material (CRM) qualified with instruments validated according to good manufacturing practices (GMP) using pharmacopeia monograph methods. It is supplied with a comprehensive certificate containing information on traceability assay results, certified purity, homogeneity tests, uncertainty statement, and stability assessment.
Lidocaine Related Compound A is a primary aromatic amine and a major metabolite of the anesthetic lidocaine. It is used as a starting material in the manufacturing of various anesthetics like lidocaine, bupivacaine, mepivacaine, etidocaine, ropivacaine, pyrrocaine, and xylazine.
The standard is a certified reference material (CRM) qualified with instruments validated according to good manufacturing practices (GMP) using pharmacopeia monograph methods. It is supplied with a comprehensive certificate containing information on traceability assay results, certified purity, homogeneity tests, uncertainty statement, and stability assessment.
Lidocaine Related Compound A is a primary aromatic amine and a major metabolite of the anesthetic lidocaine. It is used as a starting material in the manufacturing of various anesthetics like lidocaine, bupivacaine, mepivacaine, etidocaine, ropivacaine, pyrrocaine, and xylazine.
应用
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
This pharmaceutical secondary standard can also be used as follows:
This pharmaceutical secondary standard can also be used as follows:
- Development of an impurity selective reverse phase-high performance liquid chromatography (RP-HPLC) method to determine dexpanthenol, lidocaine hydrochloride, mepyramine maleate, and their related substances in topical dosage forms
- Testing a selective high-performance liquid chromatography-diode array detection (HPLC-DAD) method, developed for the simultaneous analysis of miconazole nitrate and lidocaine hydrochloride in their combined oral gel dosage form, for its stability-indicating properties
- Evaluation of a high-performance liquid chromatography-diode array detection (HPLC-DAD) procedure― for its stability indicating properties, developed to determine nitrofurazone and lidocaine hydrochloride in their combined dosage form
- Separation of 2,6-Dimethylaniline, its isomeric impurities, and other related impurities by isocratic and reverse-phase ultra-performance liquid chromatographic (UPLC) method
- analyze a binary mixture of lidocaine hydrochloride and cetylpyridinium chloride in presence of lidocaine impurity A by spectrophotometric methods
- determine lidocaine hydrochloride-related substance by analytical methods in pharmaceutical dosage forms
分析说明
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
附注
To see an example of a Certificate of Analysis for this material enter LRAC3048 in the slot below. This is an example certificate only and may not be the lot that you receive.
推荐产品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
相关产品
产品编号
说明
价格
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
195.8 °F - closed cup
闪点(°C)
91 °C - closed cup
法规信息
危险化学品
Development and Validation of RP-UPLC Method for 2, 6-Dimethylaniline, Its Isomers, and Related Compounds Using Design of Experiments
Marisetti VM and Katari NK
Chromatographia, 84(4), 359-369 (2021)
Novel Green Potentiometric Method for the Determination of Lidocaine Hydrochloride and its Metabolite 2, 6-Dimethylaniline; Application to Pharmaceutical Dosage Form and Milk
Saad AS, et al.
Electroanalysis, 30(8), 1689-1695 (2018)
Development and Validation of RP-UPLC Method for 2, 6-Dimethylaniline, Its Isomers, and Related Compounds Using Design of Experiments
Marisetti VM and Katari NK
Chromatographia, 84, 359-369 (2021)
Simultaneous determination of dexpanthenol, lidocaine hydrochloride, mepyramine maleate and their related substances by a RP-HPLC method in topical dosage forms
Doganay A, et al.
Journal of Chromatographic Science, 56(10), 903-911 (2018)
Green spectrophotometric methods for the determination of a binary mixture of lidocaine hydrochloride and cetylpyridinium chloride in the presence of dimethylaniline
Merey HA, et al.
Spectrochimica Acta Part A: Molecular Spectroscopy, 242, 118743-118743 (2020)
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