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Merck
CN

PHR1636

氮䓬斯汀

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氮卓斯汀 盐酸盐, 4-[(4-氯苯基)甲基] -2-(1-甲基氮杂-4-基)酞嗪-1-酮 盐酸盐, 盐酸氮卓斯汀, 阿斯特林

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关于此项目

经验公式（希尔记法）:
C22H24ClN3O · HCl
化学文摘社编号:
79307-93-0
分子量:
418.36
NACRES:
NA.24
PubChem Substance ID:
329823526
UNSPSC Code:
41116107
MDL number:
MFCD00242783

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产品名称

氮䓬斯汀, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

YEJAJYAHJQIWNU-UHFFFAOYSA-N

SMILES string

Cl.CN1CCCC(CC1)N2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O

InChI

1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000326
traceable to USP 1046158

API family

azelastine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... HRH1(3269)

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相关类别

Biochem/physiol Actions

H1 组胺受体拮抗剂；NF-kB 激活剂。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Azelastine Hydrochloride may be used as a pharmaceutical secondary reference standard for the determination of azelastine in plasma samples by manual-injection liquid chromatographic method using fluorescence detection.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Azelastine Hydrochloride is a long-acting antiallergic and antiasthmatic drug.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA5303 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Warning

pictograms

Exclamation mark
GHS07

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Determination of azelastine and desmethylazelastine in human plasma by high-performance liquid chromatography
Pivonka J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 420(7), 89-98 (1987)
Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs
Chand N, et al.
Allergy, 41(7), 473-478 (1986)

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