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Merck
CN
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文件

PHR1621

Supelco

硝酸布康唑

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Butoconazole nitrate, (±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole mononitrate

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About This Item

经验公式（希尔记法）:
C19H17Cl3N2S · HNO3
CAS号:
64872-77-1
分子量:
474.79
MDL编号:
MFCD00058159
UNSPSC代码:
41116107
PubChem化学物质编号:
329823515
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1082300

API类

butoconazole

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

ClC1=C(C(Cl)=CC=C1)SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3.O[N+]([O-])=O

InChI

1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)

InChI key

ZHPWRQIPPNZNML-UHFFFAOYSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Butoconazole nitrate is an antifungal agent belonging to the imidazole class, used for the treatment of vaginal candidiasis. Its mode of action includes interruption of synthesis of cellular ergosterol and disruption of cell membrane.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA5291 in the slot below. This is an example certificate only and may not be the lot that you receive.

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说明
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象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number
LRAC2477
LRAA5291

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The synthesis and antifungal activity of the enantiomers of butoconazole nitrate
Rotstein DM and Walker KAM
Tetrahedron Asymmetry, 4(7), 1521-1526 (1993)

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