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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to BP 773
traceable to USP 1392002
API类
mercaptopurine
CofA
current certificate can be downloaded
包装
pkg of 1 g
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
O.S=C1NC=Nc2nc[nH]c12
InChI
1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2
InChI key
WFFQYWAAEWLHJC-UHFFFAOYSA-N
基因信息
human ... PPAT(5471)
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相关类别
一般描述
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mercaptopurine is an anticancer and an immunosuppressive drug employed for the management of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn′s disease, etc. Its mode of action involves interference in the nucleic acid synthesis by the inhibition of purine metabolism.
应用
Mercaptopurine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, suspensions, and double drug liposomes by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAC3476 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
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产品编号
说明
价格
警示用语:
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Muta. 2 - Repr. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Mepivacaine hydrochloride
USP42-NF37
United States Pharmacopeia/National Formulary, 40(5), 2750-2750 (2019)
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF MERCAPTOPURINE-AN ANTI CANCER DRUG IN PHARMACEUTICAL FORMULATIONS
Suman P, et al.
European Journal of Biomedical AND Pharmaceutical sciences, 5(5), 752-759 (2018)
Effect of buffer and antioxidant on stability of a mercaptopurine suspension
Aliabadi HM, et al.
American Journal of Health-System Pharmacy, 65(5), 441-447 (2008)
6-mercaptopurine and daunorubicin double drug liposomes?preparation, drug-drug interaction and characterization
Agrawal V, et al.
Journal of liposome research, 15(3-4), 141-155 (2005)
相关内容
默克Supelco®标准物质不断推出或更新满足海关及法规要求的标准物质。每年我们约有上百种的新CRM或标准物质上市,在此我们尽可能多的列出满足海关及法规要求的标准物质。
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