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等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to BP 911
traceable to USP 1397006
API类
methacycline
CofA
current certificate can be downloaded
包装
pkg of 1 g
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
-10 to -25°C
SMILES字符串
Cl[H].[H][C@@]12[C@@H](O)[C@]3([H])C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
InChI
1S/C22H22N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-6,10,14-15,17,25,27-29,32H,1H2,2-3H3,(H2,23,31);1H/t10-,14-,15+,17+,22+;/m1./s1
InChI key
VZQARNDJLLWXGL-CCHMMTNSSA-N
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一般描述
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methacycline hydrochloride is one of the tetracycline antibiotics effective against a broad-spectrum of Gram-positive and Gram-negative bacteria. It is formed as an intermediate during the preparation of oxytetracycline. Its antibacterial activity is higher than that of tetracycline and oxytetracycline. It finds applications in human and veterinary medications as well as feed additives.
应用
Methacycline hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and electroanalytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
附注
To see an example of a Certificate of Analysis for this material enter LRAC2077 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics and 6-Epi-doxycycline in pharmaceutical products using porous graphitic carbon column
Monser L and Darghouth F
Journal of Pharmaceutical and Biomedical Analysis, 23(2-3), 353-362 (2000)
Ion selective PVC membrane electrode for the determination of methacycline hydrochloride in pharmaceutical formulation
Aboul-Enein H, et al.
Sensors, 2(10), 424-431 (2002)
Methacycline hydrochloride
USP42-NF37
United States Pharmacopeia/National Formulary (2013)
A G Kazemifard et al.
Journal of pharmaceutical and biomedical analysis, 16(4), 689-696 (1998-03-21)
A sensitive high-performance liquid chromatographic technique with amperometric detection has been developed for the determination of seven commercially used tetracyclines in bulk powders and pharmaceutical preparations. The technique is based on the oxidation of these compounds and their contaminants at
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