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安全信息

PHR1590

Supelco

杆菌肽

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
杆菌肽
经验公式（希尔记法）:
C66H103N17O16S
CAS号:
1405-87-4
分子量:
1422.69
EC 号:
215-786-2
MDL编号:
MFCD00062640
UNSPSC代码:
41116107
PubChem化学物质编号:
329823496
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1048007

API类

bacitracin

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

221-225 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

-10 to -25°C

SMILES字符串

CCC(C)C(N)C1=NC(CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC

InChI

1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1

InChI key

CLKOFPXJLQSYAH-RNHDWVCBSA-N

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相关类别

一般描述

Bacitracin is a polypeptide antibiotic recovered from certain strains of B. subtilis and B. licheniformis. Its mode of action involves the inhibition of bacterial cell wall synthesis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Bacitracin may be used as a pharmaceutical secondary reference standard for the determination of the analyte in serum samples and food samples by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA4581 in the slot below. This is an example certificate only and may not be the lot that you receive.

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Analysis of major components of residual bacitracin and colistin in food samples by liquid chromatography tandem mass spectrometry
Sin DW, et al.
Analytica Chimica Acta, 535(1-2), 23-31 (2005)
Determination of neomycin and bacitracin in human or rabbit serum by HPLC--MS/MS
Mascher DG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(2), 691-700 (2007)
Bacitracin: a new antibiotic produced by a member of the B. subtilis group
Johnson BA, et al.
Science (New York, N.Y.), 102(2650), 376-377 (1945)
Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls
Siewert G and Strominger JL
Proceedings of the National Academy of Sciences of the USA, 57(3), 767-767 (1967)

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