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PHR1527

醋酸地塞米松

Name: 醋酸地塞米松
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

地塞米松 21-乙酸酯, 9α-氟-16α-甲基-11β,17α,21-三羟基--1,4-孕甾二烯-3,20-二酮-21-乙酸酯, 9α-氟-16α-甲基氢化泼尼松龙-21-乙酸酯, 泼尼松龙乙酸酯

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About This Item

经验公式（希尔记法）:

C₂₄H₃₁FO₆

CAS号:

1177-87-3

分子量:

434.50

Beilstein:

2342608

EC 号:

214-646-8

MDL编号:

MFCD00027407

UNSPSC代码:

41116107

PubChem化学物质编号:

329823439

NACRES:

NA.24

生物来源

synthetic

质量水平

300

等级

certified reference material
pharmaceutical secondary standard

Agency

BP
EP
USP
traceable to Ph. Eur. D0710000
traceable to USP 1176506

蒸汽压

<0.0000001 kPa ( 25 °C)

API类

dexamethasone

CofA

current certificate can be downloaded

包装

pkg of 1 g

储存条件

protect from light (20 mm aluminium crimp seal for unused portion)

技术

HPLC: suitable
gas chromatography (GC): suitable

颜色

white

mp

460.4-464 °F (238—240°C)

溶解性

acetone: freely soluble
dichloromethane: slightly soluble
methanol: freely soluble
water: practically insoluble

应用

pharmaceutical (small molecule)

格式

neat

运输

ambient

储存温度

2-30°C

SMILES字符串

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O

InChI

1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1

InChI key

AKUJBENLRBOFTD-RPRRAYFGSA-N

基因信息

human ... NR3C1(2908)

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一般描述

Dexamethasone acetate (Decadron-LA) belongs to the class of long-acting glucocorticoids. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Dexamethasone Acetate is a steroid used for the treatment of various diseases because of its anti-inflammatory and inmunosuppresor effects. It is a common component of ointments, creams, lotions, aerosols and microemulsions.

应用

Dexamethasone Acetate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

Dexamethasone acetate is used as a pharmaceutical reference standard for the quantification the analyte in pharmaceutical formulations using liquid chromatography (LC) technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA3645 in the slot below. This is an example certificate only and may not be the lot that you receive.

警示用语：

Danger

危险声明

H360FD

预防措施声明

P201 - P202 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number

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Determination of dexamethasone acetate in cream by HPLC.

Garcia CV, et al.

Journal of Pharmaceutical and Biomedical Analysis, 31(3), 597-600 (2003)

Development and validation of HPLC method for analysis of dexamethasone acetate in microemulsions.

Urban MCC, et al.

Brazilian Journal of Pharmaceutical Sciences , 45(1), 87-92 (2009)

Dexamethasone

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 10(3), 4961-4963 (2021)

PET imaging of disease progression and treatment effects in the experimental autoimmune encephalomyelitis rat model.

Daniele de Paula Faria et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1330-1335 (2014-06-11)

The experimental autoimmune encephalomyelitis model is a model of multiple sclerosis that closely mimics the disease characteristics in humans. The main hallmarks of multiple sclerosis are neuroinflammation (microglia activation, monocyte invasion, and T-cell infiltration) and demyelination. PET imaging may be

Upregulation of nucleoside triphosphate diphosphohydrolase-1 and ecto-5'-nucleotidase in rat hippocampus after repeated low-dose dexamethasone administration.

Dunja Drakulić et al.

Journal of molecular neuroscience : MN, 55(4), 959-967 (2014-11-05)

Although dexamethasone (DEX), a synthetic glucocorticoid receptor (GR) analog with profound effects on energy metabolism, immune system, and hypothalamic-pituitary-adrenal axis, is widely used therapeutically, its impact on the brain is poorly understood. The aim of the present study was to

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醋酸地塞米松

Pharmaceutical Secondary Standard; Certified Reference Material

About This Item

属性

生物来源

质量水平

等级

Agency

蒸汽压

API类

CofA

包装

储存条件

技术

颜色

mp

溶解性

应用

格式

运输

储存温度

SMILES字符串

InChI

InChI key

基因信息

相关类别

说明

一般描述

应用

分析说明

其他说明

附注

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安全信息

象形图

警示用语：

危险声明

预防措施声明

危险分类

WGK

闪点(°F)

闪点(°C)

法规信息

文件

分析证书(COA)

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