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Merck
CN

PHR1491

硫酸新霉素

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

硫酸新霉素

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关于此项目

经验公式（希尔记法）:
C23H46N6O13 · xH2SO4
化学文摘社编号:
1405-10-3
分子量:
614.64 (free base basis)
UNSPSC Code:
41116107
EC Number:
215-773-1
NACRES:
NA.24

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产品名称

硫酸新霉素, Pharmaceutical Secondary Standard; Certified Reference Material

SMILES string

[S](=O)(=O)(O)O.N[C@H]1[C@H](O[C@@H]([C@H]([C@@H]1O)O)CN)O[C@H]2[C@@H]([C@H]([C@@H](C[C@@H]2N)N)O)O[C@@H]3O[C@@H]([C@H]([C@H]3O)OC4O[C@H]([C@H]([C@@H]([C@H]4N)O)O)CN)CO

InChI key

OIXVKQDWLFHVGR-GQTDVWSESA-N

InChI

1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22?,23+;/m1./s1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. N0400000
traceable to Ph. Eur. N0401000
traceable to USP 1458009

API family

neomycin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

Quality Level

300

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相关类别

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Neomycin sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in eye ointments by thin layer chromatography.

General description

Neomycin sulfate is an aminoglycoside broad spectrum antibiotic produced by the fermentation of Streptomyces fradiae or Streptomyces decaris.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2086 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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Simultaneous identification and quantitative determination of neomycin sulfate, polymixin B sulfate, zinc bacytracin and methyl and propyl hydroxybenzoates in ophthalmic ointment by TLC.
Krzek J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(4), 629-636 (2001)
Analysis of neomycin sulfate and framycetin sulfate by high-performance liquid chromatography using evaporative light scattering detection.
Clarot I, et al.
Journal of Chromatography A, 1087(1-2), 236-244 (2005)
Siddhi Gupta et al.
Antimicrobial agents and chemotherapy, 63(11) (2019-08-21)
Interkingdom polymicrobial biofilms formed by Gram-positive Staphylococcus aureus and Candida albicans pose serious threats of chronic systemic infections due to the absence of any common therapeutic target for their elimination. Herein, we present the structure-activity relationship (SAR) of membrane-targeting cholic
Lokender Kumar et al.
Frontiers in microbiology, 12, 598498-598498 (2021-02-16)
Pseudomonas aeruginosa utilizes the quorum sensing (QS) system to strategically coordinate virulence and biofilm formation. Targeting QS pathways may be a potential anti-infective approach to treat P. aeruginosa infections. In the present study, we define cephalosporins' anti-QS activity using Chromobacterium

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