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Merck
CN

PHR1443

厄贝沙坦

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one

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关于此项目

经验公式（希尔记法）:
C25H28N6O
化学文摘社编号:
138402-11-6
分子量:
428.53
MDL编号:
MFCD00864464
UNSPSC代码:
41116107
PubChem化学物质编号:
329822604
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0001166
traceable to USP 1347700

API类

irbesartan

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5

InChI

1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChI key

YOSHYTLCDANDAN-UHFFFAOYSA-N

基因信息

human ... AGTR1(185)

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相关类别

一般描述

Irbesartan is a potent, long-acting “sartan” class, nonpeptide, angiotensin II receptor antagonist utilized for the management of hypertension as well as heart failure in clinical patients. It shows high selectivity for the AT1 subtype (angiotensin I), and effectively reduces the probabilities of cardiac failure, myocardial infarction, sudden death, etc.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Irbesartan may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2897 in the slot below. This is an example certificate only and may not be the lot that you receive.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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A novel dilute and shoot HPLC assay method for quantification of irbesartan and hydrochlorothiazide in combination tablets and urine using second generation C18-bonded monolithic silica column with double gradient elution
Koyuturk S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 97(2), 103-110 (2014)
Determination of hydrochlorothiazide and irbesartan in pharmaceuticals by fourth-order UV derivative spectrophotometry
Vetuschi C, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(8), 665-670 (2005)
H-Point Standard Addition Method for Simultaneous Spectrophotometric Determination of Irbesartan, hydrochlorothiazide and Telmisartan in tablets
Sivasubramanian L and Lakshmi KS
International Journal of Research in Pharmacy and Chemistry, 4(2), 373-380 (2014)
Simultaneous determination of olmesartan medoxomil and irbesartan and hydrochlorothiazide in pharmaceutical formulations and human serum using high performance liquid chromatography
Sultana N, et al.
Se Pu / Chinese Journal of Chromatography, 26(5), 544-549 (2008)
Electrochemical determination of antihypertensive drug irbesartan in pharmaceuticals
Gupta VK, et al.
Analytical biochemistry, 410(2), 266-271 (2011)
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