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Merck
CN
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文件

PHR1403

Supelco

酚妥拉明

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

酚妥拉明 甲磺酸盐, 2-(N-[m-羟基苯基]-p-甲苯氨基甲基)咪唑啉

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About This Item

线性分子式:
C17H19N3O · CH3SO3H
CAS号:
65-28-1
分子量:
377.46
EC 号:
200-604-6
MDL编号:
MFCD00134201
UNSPSC代码:
41116107
PubChem化学物质编号:
329823376
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0001127
traceable to USP 1530004

API类

phentolamine

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

180-182 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI

1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

InChI key

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

基因信息

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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相关类别

一般描述

Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Phentolamine Mesylate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chemiluminescence technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

α-肾上腺素受体拮抗剂；外周血管舒张剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3261 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number
LRAD3732
LRAC3261
LRAA9189
LRAA2197

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Long-term safety and efficacy of oral phentolamine mesylate (Vasomax?) in men with mild to moderate erectile dysfunction
Padma-Nathan H, et al.
International Journal of Impotence Research, 14(4), 266-266 (2002)
Phentolamine mesylate relaxes penile corpus cavernosum tissue by adrenergic and non-adrenergic mechanisms
Traish A, et al.
International Journal of Impotence Research, 10(4), 215-215 (1998)
Sensitive chemiluminescence determination of phentolamine mesylate and phenoxybenzamine hydrochloride based on K3Fe (CN) 6-H2O2-fluorescein
Xing L, et al.
Journal of Luminescence, 137(4), 162-167 (2013)
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate
Moore PA, et al.
Anesthesia Progress, 55(2), 40-48 (2008)
Xianming Su et al.
Journal of cardiovascular pharmacology, 65(1), 62-71 (2014-09-30)
Previous studies have found that Danhong injection (DHI), an extensively used herbal extract preparation in China, might be a powerful vasodilator. The aims of this study were to determine the vascular activity of DHI and its effects on arteries of

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