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COO原产地证书/COA分析证书

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PHR1399

二丙酸倍他米松

Name: 二丙酸倍他米松
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Betamethasone 17,21-dipropionate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

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About This Item

经验公式（希尔记法）:

C₂₈H₃₇FO₇

CAS号:

5593-20-4

分子量:

504.59

EC 号:

227-005-2

MDL编号:

MFCD00133140

UNSPSC代码:

41116107

PubChem化学物质编号:

329823373

NACRES:

NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. B1040000
traceable to USP 1067704

API类

betamethasone

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

[H][C@@]12C[C@H](C)[C@](OC(=O)CCl)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)C3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C27H34ClFO7/c1-5-22(33)35-14-21(32)27(36-23(34)13-28)15(2)10-19-18-7-6-16-11-17(30)8-9-24(16,3)26(18,29)20(31)12-25(19,27)4/h8-9,11,15,18-20,31H,5-7,10,12-14H2,1-4H3/t15-,18-,19-,20-,24-,25-,26?,27-/m0/s1

InChI key

UOCNBCVPZWLUKX-HOBFILNXSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Betamethasone dipropionate is a synthetic glucocorticoid, used as an anti-inflammatory agent to treat different skin disorders.

应用

Betamethasone dipropionate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA2175 in the slot below. This is an example certificate only and may not be the lot that you receive.

1067045

1067726

Betamethasone Dipropionate Related Compound B, United States Pharmacopeia (USP) Reference Standard

1067737

Betamethasone Dipropionate Related Compound C, United States Pharmacopeia (USP) Reference Standard

1067760

Betamethasone Dipropionate Related Compound F , United States Pharmacopeia (USP) Reference Standard

1067781

Betamethasone dipropionate Related Compound H, United States Pharmacopeia (USP) Reference Standard

象形图

GHS08

警示用语：

Danger

危险声明

H360FD,H373

预防措施声明

P202 - P260 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 1B - STOT RE 2

靶器官

Liver,Kidney,Endocrine system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

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RP-HPLC method for simultaneous determination of butenafine hydrochloride and betamethasone dipropionate in a cream formulation.

Bhosale SD and Rajput SJ

Journal of AOAC (Association of Official Analytical Chemists) International, 94(1), 106-109 (2011)

A validated simultaneous RP-HPLC method for determination of betamethasone dipropionate and tolnaftate in combined semisolid formulation.

Saha CN and Bhattacharya S

International Journal of ChemTech Research, 1(3), 671-674 (2009)

Development and validation of a stability-indicating HPLC method for simultaneous determination of salicylic acid, betamethasone dipropionate and their related compounds in Diprosalic Lotion?

Shou M, et al.

Journal of Pharmaceutical and Biomedical Analysis, 50(3), 356-361 (2009)

Validation of a liquid chromatography method for the simultaneous determination of several nonsteroidal anti-inflammatory drugs in human plasma for therapeutic drug monitoring.

Sally A Helmy et al.

Therapeutic drug monitoring, 36(1), 100-107 (2013-11-26)

Diflunisal, naproxen, ketoprofen, etodolac, mefenamic acid, rofecoxib, and celecoxib are nonsteroidal anti-inflammatory drugs, which have analgesics, antipyretics, and anti-inflammatory activities. The aim of this work was to develop and validate a simple assay that could be implemented in most laboratories

Safety and efficacy of calcipotriene plus betamethasone dipropionate topical suspension in the treatment of extensive scalp psoriasis in adolescents ages 12 to 17 years.

Lawrence F Eichenfield et al.

Pediatric dermatology, 32(1), 28-35 (2014-11-22)

The objective of this study was to assess the safety and efficacy of the fixed combination calcipotriene 0.005% plus betamethasone dipropionate 0.064% topical suspension in adolescents with extensive scalp psoriasis. In this phase II, open-label, 8-week study, adolescents with psoriasis

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二丙酸倍他米松

Pharmaceutical Secondary Standard; Certified Reference Material

About This Item

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属性

等级

质量水平

Agency

API类

CofA

技术

应用

包装形式

储存温度

SMILES字符串

InChI

InChI key

说明

一般描述

应用

生化/生理作用

分析说明

其他说明

附注

相关产品

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安全信息

象形图

警示用语：

危险声明

预防措施声明

危险分类

靶器官

储存分类代码

WGK

闪点(°F)

闪点(°C)

法规信息

文件

分析证书(COA)

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