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安全信息

PHR1353

Supelco

雌二醇

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

β-雌二醇, 17β-雌二醇, 1，3，5-雌三烯-3，17β-二醇, 3,17β-二羟基-1,3,5(10)-雌三烯, 二氢卵泡素

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About This Item

经验公式（希尔记法）:
C18H24O2
CAS号:
50-28-2
分子量:
272.38
Beilstein:
1914275
EC 号:
200-023-8
MDL编号:
MFCD00003693
UNSPSC代码:
41116107
PubChem化学物质编号:
329823337
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 729
traceable to Ph. Eur. E1620000
traceable to USP 1250008

API类

estradiol

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

176-180 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

基因信息

human ... ESR1(2099)

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Estradiol is a steroid hormone present naturally in the human body. The availability of this hormone is quintessential in older women as it is a determinant of menopausal syndromes. It is utilized for the prevention of cardiovascular diseases.

应用

Estradiol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

绝经前卵巢分泌的主要雌激素。雌激素通过调节基因转录并因此调节蛋白质合成来指导胚胎发生和青春期女性表型的发展。 它还诱导促性腺激素的产生，进而诱导排卵。 暴露于雌二醇会增加乳腺癌的发生率和增殖。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3704 in the slot below. This is an example certificate only and may not be the lot that you receive.

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

相关产品

产品编号
说明
价格

1250008

雌二醇, United States Pharmacopeia (USP) Reference Standard

Y0000314

Estradiol for peak identification, European Pharmacopoeia (EP) Reference Standard

E1620000

雌二醇 半水合物, European Pharmacopoeia (EP) Reference Standard

E1600000

苯甲酸雌二醇, European Pharmacopoeia (EP) Reference Standard

Y0000046

β-雌二醇 17-戊酸酯, European Pharmacopoeia (EP) Reference Standard

Y0000852

系统适用性试验用苯甲酸雌二醇, European Pharmacopoeia (EP) Reference Standard

1252003

环戊酸雌二醇, United States Pharmacopeia (USP) Reference Standard

1251000

苯甲酸雌二醇, United States Pharmacopeia (USP) Reference Standard

BP729

雌二醇 半水合物, British Pharmacopoeia (BP) Assay Standard

1254009

β-雌二醇 17-戊酸酯, United States Pharmacopeia (USP) Reference Standard

1250041

β-雌二醇-6-酮, United States Pharmacopeia (USP) Reference Standard

1250020

Estradiol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1252193

Estradiol cypionate System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

Y0001823

β-雌二醇 17-戊酸酯, European Pharmacopoeia (EP) Reference Standard

BP396

苯甲酸雌二醇, British Pharmacopoeia (BP) Reference Standard

1254031

Estradiol Valerate Identification Mixture, United States Pharmacopeia (USP) Reference Standard

PHR2228

β-Estradiol 3-methyl ether, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2227

雌二醇杂质 L, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2839

Estradiol Cypionate, certified reference material, pharmaceutical secondary standard

PHR2857

β-雌二醇 17-戊酸酯, certified reference material, pharmaceutical secondary standard

PHR2858

β-雌二醇-3-苯甲酸酯, certified reference material, pharmaceutical secondary standard

PHR2859

β-雌二醇-6-酮, pharmaceutical secondary standard, certified reference material

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Danger

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number
LRAD0199
LRAD4797
LRAC5166
LRAD2235
LRAC3704

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Prediction of internal standards in reversed-phase liquid chromatography: II. Selectivity optimization and internal standard prediction for the quantitation of estradiol and levonorgestrel in a transdermal drug delivery formulation based on the linear solvation energy relationships
Li, J and Shah DS
Journal of Chromatography A, 954(1), 159-171 (2002)
HPLC determination of estradiol, its degradation product, and preservatives in new topical formulation Estrogel HBF.
Novakova L, et al.
Analytical and Bioanalytical Chemistry, 379(5-6), 781-787 (2004)
High-efficiency liquid chromatography in pharmaceutical analysis
Bailey F. and Brittain PN
Journal of Chromatography A, 83(3), 431-437 (1973)
Advantages of application of UPLC in pharmaceutical analysis.
Novakova L, et al.
Talanta, 68(3), 908-918 (2006)
Amit Cohen et al.
Zebrafish, 11(5), 462-478 (2013-06-19)
Estrogen is a steroid hormone that has been implicated in a variety of cellular and physiological processes and in the development of diseases such as cancer. Here we show a remarkable widespread microRNA (miRNA) downregulation in the zebrafish (Danio rerio)
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Ultrapure Water for LC MS Biomedical Analyses

This study assesses the suitability of ultrapure water from a Milli-Q® water system for sensitive LC-MS analyses of hormones.

LC-MS法分析自来水中的激素

Milli-Q®超纯水系统产水不含有机污染物，包括实验室自来水中的激素，非常适合高度灵敏的LC-MS/MS分析。

LC-MS Analysis of Hormones in Tap Water

Milli-Q® ultrapure water systems deliver water free of organic contaminants , including hormones present in a lab's tap water, making it suitable for the most sensitive LC-MS/MS analyses.

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