PHR1343
磺胺嘧啶
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
磺胺嘧啶, N-2-嘧啶基-4-氨基苯磺酰胺, N1-(嘧啶-2-基)磺胺
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经验公式（希尔记法）:
C10H10N4O2S
化学文摘社编号:
分子量:
250.28
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-685-8
Beilstein/REAXYS Number:
6733588
MDL number:
产品名称
磺胺嘧啶, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
SEEPANYCNGTZFQ-UHFFFAOYSA-N
InChI
1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. S1800000
traceable to USP 1625009
API family
sulfadiazine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
253 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application
Sulfadiazine may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Sulfadiazine is a bacteriostatic drug, that belongs to the class of medication referred as sulfonamide antibiotics. It is generally used in the treatment of cerebral meningitis, pneumonia, staphylococcal and streptococcal sepsis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3953 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
33 - Antimicrobial Drugs
Synthesis of Essential Drugs, 499-523 (2006)
Determination of the content and the related substances of silver sulfadiazine gel by HPLC
Li Y, et al.
Chinese Journal of Hospital Pharmacy, 24(8), 474-474 (2004)
Sulfadiazine
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 4106-4106 (2018)
Sulfonamide antibiotics
Connor EE
Primary Care Update for OB/GYNS, 5(1), 32-35 (1998)
Simultaneous determination of enrofloxacin, silver sulfadiazine, hydrocortisone acetate, hydrocortisone sodium succinate, and preservative excipients in pharmaceutical preparations using HPLC-DAD method
Rosa AM, et al.
Chromatographia, 80(11), 1641-1649 (2017)
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