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Merck
CN

PHR1336

Supelco

尼美舒利

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

尼美舒利, N-(4-硝基-2-苯氧基苯基)甲磺酰胺

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About This Item

经验公式(希尔记法):
C13H12N2O5S
CAS号:
分子量:
308.31
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to Ph. Eur. N0845000

API类

nimesulide

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES字符串

CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O

InChI

1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

InChI key

HYWYRSMBCFDLJT-UHFFFAOYSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor that can potentially be used as a therapeutic agent for the treatment of inflammatory conditions. It is also a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic and antipyretic characters.

应用

Nimesulide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

高选择性环氧化酶-2 抑制剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA1070 in the slot below. This is an example certificate only and may not be the lot that you receive.

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

危险分类

Acute Tox. 3 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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在文件库中查找您最近购买产品的文档。

访问文档库

Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry
Altinoz S and Dursun OO
Journal of Pharmaceutical and Biomedical Analysis, 22(1), 175-182 (2000)
Validated HPTLC method for nimesulide and dicyclomine hydrochloride in formulation
Dhaneshwar SR, et al.
Journal of Pharmacy Research, 4(7), 2288-2290 (2011)
Improved high-performance liquid chromatographic assay for nimesulide
Jaworowicz Jr DJ, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 723(1-2), 293-299 (1999)
Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids
Nageswara Rao R, et al.
Biomedical Chromatography, 19(5), 362-368 (2005)
Development and validation of a novel RP-HPLC method for simultaneous determination of paracetamol, phenylephrine hydrochloride, caffeine, cetirizine and nimesulide in tablet formulation.
Dewani AP, et al.
Arabian Journal of Chemistry, 8(4), 591-598 (2015)

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